Abstract
An overview of the current trends within protein expression profiling is given where multidimensional separation of both gel- and liquid-phase techniques linked to mass spectrometry is viewed as a major route in the global proteome mapping. A clear trend in these biochemical developments is the effort to sequence and identify low-abundant protein expressions where assay miniaturization and integrated sample processing plays a central role. Two areas of miniaturization within the proteomics field are addressed: (i) sample cleanup and enrichment, and (ii) silicon microstructure developments for protein chip microarrays.
| Original language | English |
|---|---|
| Pages (from-to) | 3521-3532 |
| Journal | Electrophoresis |
| Volume | 24 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 2003 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Biomedical Engineering (011200011), Analytical Chemistry (S/LTH) (011001004)
Subject classification (UKÄ)
- Medical Engineering
- Analytical Chemistry
Free keywords
- proteomics
- miniaturization
- protein expression profiling
- review