New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

Alexandra Fagerström; Mikael Nilsson; Ulf Berg; Roland Isaksson

doi:10.1039/b605603b

New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

Alexandra Fagerström, Mikael Nilsson, Ulf Berg, Roland Isaksson

Centre for Analysis and Synthesis

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Abstract

Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.

Original language	English
Pages (from-to)	3067-3076
Journal	Organic and Biomolecular Chemistry
Volume	4
Issue number	16
DOIs	https://doi.org/10.1039/b605603b
Publication status	Published - 2006

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

Subject classification (UKÄ)

Organic Chemistry

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10.1039/b605603b

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title = "New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A",

abstract = "Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.",

author = "Alexandra Fagerstr{\"o}m and Mikael Nilsson and Ulf Berg and Roland Isaksson",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)",

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AU - Fagerström, Alexandra

AU - Nilsson, Mikael

AU - Berg, Ulf

AU - Isaksson, Roland

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

PY - 2006

Y1 - 2006

N2 - Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.

AB - Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.

U2 - 10.1039/b605603b

DO - 10.1039/b605603b

M3 - Article

SN - 1477-0539

VL - 4

SP - 3067

EP - 3076

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 16

ER -

New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

Abstract

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