Next-Generation Gene Therapy for Parkinson's Disease Using Engineered Viral Vectors

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent technological and conceptual advances have resulted in a plethora of exciting novel engineered adeno associated viral (AAV) vector variants. They all have unique characteristics and abilities. This review summarizes the development and their potential in treating Parkinson's disease (PD). Clinical trials in PD have shown over the last decade that AAV is a safe and suitable vector for gene therapy but that it also is a vehicle that can benefit significantly from improvement in specificity and potency. This review provides a concise collection of the state-of-the-art for synthetic capsids and their utility in PD. We also summarize what therapeutical strategies may become feasible with novel engineered vectors, including genome editing and neuronal rejuvenation.

Original languageEnglish
Pages (from-to)S209-S217
JournalJournal of Parkinson's Disease
Volume11
Issue numbers2
DOIs
Publication statusPublished - 2021

Subject classification (UKÄ)

  • Neurosciences

Free keywords

  • clinical trial
  • dependovirus
  • gene editing
  • Genetic therapy
  • neuroprotection
  • Parkinson's disease
  • rejuvenation

Fingerprint

Dive into the research topics of 'Next-Generation Gene Therapy for Parkinson's Disease Using Engineered Viral Vectors'. Together they form a unique fingerprint.

Cite this