Nicotine does not affect plasma lipoprotein concentrations in healthy men

M Quensel, Carl-David Agardh, Peter Nilsson-Ehle

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of nicotine administration (2 mg eight-times daily as nicotine chewing gum for two weeks) on plasma lipid and lipoprotein concentrations were studied in young healthy volunteers. Plasma levels of the nicotine metabolite, cotinine, reached levels comparable to those seen in smokers. Plasma concentrations of triglyceride, cholesterol, HDL cholesterol, LDL cholesterol, and apolipoproteins AI and B, were determined repeatedly before, during and after cessation of nicotine intake. All these variables, as well as the activities of lipoprotein lipase and hepatic lipase in post-heparin plasma, remained unchanged throughout the study. The results strongly suggest that the effects of smoking on plasma lipoprotein metabolism are not mediated via nicotine, and indicate that nicotine chewing gum, when used therapeutically in anti-smoking programmes, does not carry the same metabolic side effects as smoking.
Original languageEnglish
Pages (from-to)149-153
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume49
Issue number2
DOIs
Publication statusPublished - 1989

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510), Division of Clinical Chemistry and Pharmacology (013250300)

Subject classification (UKÄ)

  • Pharmacology and Toxicology
  • Endocrinology and Diabetes
  • Medicinal Chemistry

Free keywords

  • plasma lipoproteins
  • plasma lipids
  • nicotine intake
  • lipolytic enzymes
  • cotinine concentrations

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