Abstract
OBJECTIVES: The aim of this population-based case-control study was to investigate whether a high body mass index (BMI) is a risk factor for clinical hand osteoarthritis (OA).
METHOD: Persons living in Ullensaker municipality in Norway who were aged 20-52 years in 1990 reported height and weight in 1990, 1994, 2004, and 2010 (n = 1276). Cases (clinical hand OA in 2010, n = 59) were compared to controls (participants without self-reported OA or hand pain in 2010, n = 805) with regard to the prospectively measured BMI by means of a generalized estimating equation (GEE) analysis adjusted for age, sex, time, and education.
RESULTS: The mean age of hand OA cases was 64 (SD = 7.5) years in 2010 and 78% were women. There was no association between total average BMI over the entire period and later clinical hand OA (p = 0.320). Cases had a higher mean BMI in 1990 [unstandardized B = 0.93, 95% confidence interval (CI) 0.07-1.79] and in 1994 (B = 0.75, 95% CI 0.22-1.28) but there were no differences between the groups in 2004 or 2010.
CONCLUSIONS: The study lend support to the hypothesis that having a higher BMI when young or middle-aged might be associated with later hand OA.
| Original language | English |
|---|---|
| Pages (from-to) | 409-15 |
| Number of pages | 7 |
| Journal | Scandinavian Journal of Rheumatology |
| Volume | 43 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
Subject classification (UKÄ)
- Orthopedics
Free keywords
- Adult
- Age Factors
- Aged
- Body Mass Index
- Case-Control Studies
- Female
- Hand Joints/physiopathology
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Models, Statistical
- Norway
- Obesity/complications
- Osteoarthritis/epidemiology
- Prospective Studies
- Retrospective Studies
- Risk Factors
- Surveys and Questionnaires
