Non-covalent molecular imprinting with emphasis on its application in separation and drug development

Huiqi Zhang, Lei Ye, Klaus Mosbach

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

Abstract

The molecular imprinting technique can be defined as the formation of specific nano-sized cavities by means of template-directed synthesis. The resulting molecularly imprinted polymers (MIPs), which often have an affinity and a selectivity approaching those of antibody-antigen systems, have thus been coined "artificial antibodies." MIPs are characterized by their high specificity, ease of preparation, and their thermal and chemical stability. They have been widely studied in connection with many potential applications, including their use for separation and isolation purposes, as antibody mimics (biomimetic assays and sensors), as enzyme mimics, in organic synthesis, and in drug delivery. The non-covalent imprinting approach, developed mainly in Lund, has proven to be more versatile than the alternative covalent approach because of its preparation being less complicated and of the broad selection of functional monomers and possible target molecules that are available. The paper presents a review of studies of this versatile technique in the areas of separation and drug development, with emphasis being placed on work carried out in our laboratory. Copyright (c) 2006 John Wiley & Sons, Ltd.
Original languageEnglish
Title of host publicationJournal of Molecular Recognition
PublisherJohn Wiley & Sons Inc.
Pages248-259
Volume19
DOIs
Publication statusPublished - 2006
EventBioaffinity 2005 - Upsala, Sweden
Duration: 2005 Aug 142005 Aug 18

Publication series

Name
Number4
Volume19
ISSN (Print)1099-1352
ISSN (Electronic)0952-3499

Conference

ConferenceBioaffinity 2005
Country/TerritorySweden
CityUpsala
Period2005/08/142005/08/18

Subject classification (UKÄ)

  • Biochemistry and Molecular Biology

Keywords

  • drug
  • non-covalent approach
  • separation
  • molecular imprinting
  • development

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