Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosus

Mary Lu; Sasha Bernatsky; Rosalind Ramsey-Goldman; Michelle Petri; Susan Manzi; Murray B. Urowitz; Dafna Gladman; Paul R. Fortin; Ellen M. Ginzler; Edward Yelin; Sang-Cheol Bae; Daniel J. Wallace; Soren Jacobsen; Mary Anne Dooley; Christine A. Peschken; Graciela S. Alarcon; Ola Nived; Lena Gottesman; Lindsey A. Criswell; Gunnar Sturfelt; Lene Dreyer; Jennifer L. Lee; Ann E. Clarke

doi:10.1159/000350165

Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosus

Mary Lu, Sasha Bernatsky, Rosalind Ramsey-Goldman, Michelle Petri, Susan Manzi, Murray B. Urowitz, Dafna Gladman, Paul R. Fortin, Ellen M. Ginzler, Edward Yelin, Sang-Cheol Bae, Daniel J. Wallace, Soren Jacobsen, Mary Anne Dooley, Christine A. Peschken, Graciela S. Alarcon, Ola Nived, Lena Gottesman, Lindsey A. Criswell, Gunnar SturfeltLene Dreyer, Jennifer L. Lee, Ann E. Clarke

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation. (C) 2013 S. Karger AG, Basel

Original language	English
Pages (from-to)	235-240
Journal	Oncology
Volume	85
Issue number	4
DOIs	https://doi.org/10.1159/000350165
Publication status	Published - 2013

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

Systemic lupus erythematosus
Malignancy
Cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000350165

Cite this

Lu, M., Bernatsky, S., Ramsey-Goldman, R., Petri, M., Manzi, S., Urowitz, M. B., Gladman, D., Fortin, P. R., Ginzler, E. M., Yelin, E., Bae, S.-C., Wallace, D. J., Jacobsen, S., Dooley, M. A., Peschken, C. A., Alarcon, G. S., Nived, O., Gottesman, L., Criswell, L. A., ... Clarke, A. E. (2013). Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosus. Oncology, 85(4), 235-240. https://doi.org/10.1159/000350165

@article{1d2d69dd2ce74bbab4ef1604476f8231,

title = "Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosus",

abstract = "Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation. (C) 2013 S. Karger AG, Basel",

keywords = "Systemic lupus erythematosus, Malignancy, Cancer",

author = "Mary Lu and Sasha Bernatsky and Rosalind Ramsey-Goldman and Michelle Petri and Susan Manzi and Urowitz, {Murray B.} and Dafna Gladman and Fortin, {Paul R.} and Ginzler, {Ellen M.} and Edward Yelin and Sang-Cheol Bae and Wallace, {Daniel J.} and Soren Jacobsen and Dooley, {Mary Anne} and Peschken, {Christine A.} and Alarcon, {Graciela S.} and Ola Nived and Lena Gottesman and Criswell, {Lindsey A.} and Gunnar Sturfelt and Lene Dreyer and Lee, {Jennifer L.} and Clarke, {Ann E.}",

year = "2013",

doi = "10.1159/000350165",

language = "English",

volume = "85",

pages = "235--240",

journal = "Oncology",

issn = "1423-0232",

publisher = "Karger",

number = "4",

}

Lu, M, Bernatsky, S, Ramsey-Goldman, R, Petri, M, Manzi, S, Urowitz, MB, Gladman, D, Fortin, PR, Ginzler, EM, Yelin, E, Bae, S-C, Wallace, DJ, Jacobsen, S, Dooley, MA, Peschken, CA, Alarcon, GS, Nived, O, Gottesman, L, Criswell, LA, Sturfelt, G, Dreyer, L, Lee, JL & Clarke, AE 2013, 'Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosus', Oncology, vol. 85, no. 4, pp. 235-240. https://doi.org/10.1159/000350165

TY - JOUR

T1 - Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosus

AU - Lu, Mary

AU - Bernatsky, Sasha

AU - Ramsey-Goldman, Rosalind

AU - Petri, Michelle

AU - Manzi, Susan

AU - Urowitz, Murray B.

AU - Gladman, Dafna

AU - Fortin, Paul R.

AU - Ginzler, Ellen M.

AU - Yelin, Edward

AU - Bae, Sang-Cheol

AU - Wallace, Daniel J.

AU - Jacobsen, Soren

AU - Dooley, Mary Anne

AU - Peschken, Christine A.

AU - Alarcon, Graciela S.

AU - Nived, Ola

AU - Gottesman, Lena

AU - Criswell, Lindsey A.

AU - Sturfelt, Gunnar

AU - Dreyer, Lene

AU - Lee, Jennifer L.

AU - Clarke, Ann E.

PY - 2013

Y1 - 2013

N2 - Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation. (C) 2013 S. Karger AG, Basel

AB - Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation. (C) 2013 S. Karger AG, Basel

KW - Systemic lupus erythematosus

KW - Malignancy

KW - Cancer

U2 - 10.1159/000350165

DO - 10.1159/000350165

M3 - Article

C2 - 24107608

SN - 1423-0232

VL - 85

SP - 235

EP - 240

JO - Oncology

JF - Oncology

IS - 4

ER -

Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosus

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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