Novel Aspects Pertaining to the Relationship of Waldenstrom's Macroglobulinemia, IgM Monoclonal Gammopathy of Undetermined Significance, Polyclonal Gammopathy, and Hypoglobulinemia

Mary L. McMaster, Sigurdur Y. Kristinsson, Ingemar Turesson, Magnus Bjorkholm, Ola Landgren

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

11 Citations (SciVal)

Abstract

Waldenstrom's macroglobulinemia (WM) is associated with a precursor condition, monoclonal gammopathy of undetermined significance (MGUS) of immunoglobulin-M (IgM) type. The etiology of these conditions is unknown. Recent studies at the population level have provided new data regarding familial aggregation of these disorders and other B-cell malignancies. Studies of familial clusters of WM have demonstrated an increased frequency of IgM MGUS compared with the general population and have provided new data suggesting that the phenotypic spectrum might also include polyclonal gammopathy and hypoglobulinemia. While the preponderance of immunoglobulin abnormalities in relatives of WM cases involves IgM, other immunoglobulin types (IgG and IgA) might also be affected. Large collaborative studies are needed to confirm these findings, which present an opportunity to define the earliest lesion(s) in the WM oncogenic pathway.
Original languageEnglish
Title of host publicationClinical Lymphoma & Myeloma
PublisherCIG Media Group
Pages19-22
Volume9
DOIs
Publication statusPublished - 2009
Event5th International Workshop on Waldenstroms Macroglobulinemia - Stockholm, SWEDEN
Duration: 2008 Oct 152008 Oct 19

Publication series

Name
Number1
Volume9
ISSN (Print)1557-9190

Conference

Conference5th International Workshop on Waldenstroms Macroglobulinemia
Period2008/10/152008/10/19

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

Subject classification (UKÄ)

  • Clinical Medicine

Keywords

  • Precursor disease
  • IgM
  • Genetic susceptibility
  • Hypergammaglobulinemia

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