Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.

Svante Vikingsson; David Andersson; Sven Almer; Curt Peterson; Ulf Hindorf

doi:10.1016/j.crohns.2014.08.009

Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.

Svante Vikingsson, David Andersson, Sven Almer, Curt Peterson, Ulf Hindorf

Medicine/Emergency Medicine, Lund

Research output: Contribution to journal › Article › peer-review

Abstract

The thiopurines are widely used in the treatment of inflammatory bowel disease, but are limited by poor dose-effect relationship. The objective was to assess the ability of a novel assay, determining the mono-, di-, and triphosphates, of thioguanine as well as methylthioinosine as individual metabolites in erythrocytes, to predict clinical outcome compared to a routine assay, determining metabolites as sums.

Original language	English
Pages (from-to)	1702-1709
Journal	Journal of Crohn's & Colitis
Volume	8
Issue number	12
DOIs	https://doi.org/10.1016/j.crohns.2014.08.009
Publication status	Published - 2014

Subject classification (UKÄ)

Gastroenterology and Hepatology

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10.1016/j.crohns.2014.08.009

http://www.ncbi.nlm.nih.gov/pubmed/25239576?dopt=Abstract

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title = "Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.",

abstract = "The thiopurines are widely used in the treatment of inflammatory bowel disease, but are limited by poor dose-effect relationship. The objective was to assess the ability of a novel assay, determining the mono-, di-, and triphosphates, of thioguanine as well as methylthioinosine as individual metabolites in erythrocytes, to predict clinical outcome compared to a routine assay, determining metabolites as sums.",

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AU - Andersson, David

AU - Almer, Sven

AU - Peterson, Curt

AU - Hindorf, Ulf

PY - 2014

Y1 - 2014

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AB - The thiopurines are widely used in the treatment of inflammatory bowel disease, but are limited by poor dose-effect relationship. The objective was to assess the ability of a novel assay, determining the mono-, di-, and triphosphates, of thioguanine as well as methylthioinosine as individual metabolites in erythrocytes, to predict clinical outcome compared to a routine assay, determining metabolites as sums.

U2 - 10.1016/j.crohns.2014.08.009

DO - 10.1016/j.crohns.2014.08.009

M3 - Article

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SP - 1702

EP - 1709

JO - Journal of Crohn's & Colitis

JF - Journal of Crohn's & Colitis

IS - 12

ER -

Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.

Abstract

Subject classification (UKÄ)

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