Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction

Sabin Llona-Minguez; Adam Throup; Emilie Steiner; Molly Lightowler; Sandra Van der Haegen; Evert Homan; Lars Eriksson; Pål Stenmark; Annika Jenmalm-Jensen; Thomas Helleday

doi:10.1039/c7ob02069d

Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction

Sabin Llona-Minguez, Adam Throup, Emilie Steiner, Molly Lightowler, Sandra Van der Haegen, Evert Homan, Lars Eriksson, Pål Stenmark, Annika Jenmalm-Jensen, Thomas Helleday

Stockholm University

Research output: Contribution to journal › Article › peer-review

Abstract

Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.

Original language	English
Pages (from-to)	7758-7764
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	37
DOIs	https://doi.org/10.1039/c7ob02069d
Publication status	Published - 2017 Sept 26
Externally published	Yes

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10.1039/c7ob02069d

Cite this

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abstract = "Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between {"}drug-like{"} molecules and natural products.",

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AU - Llona-Minguez, Sabin

AU - Throup, Adam

AU - Steiner, Emilie

AU - Lightowler, Molly

AU - Van der Haegen, Sandra

AU - Homan, Evert

AU - Eriksson, Lars

AU - Stenmark, Pål

AU - Jenmalm-Jensen, Annika

AU - Helleday, Thomas

PY - 2017/9/26

Y1 - 2017/9/26

N2 - Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.

AB - Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.

U2 - 10.1039/c7ob02069d

DO - 10.1039/c7ob02069d

M3 - Article

C2 - 28891572

SN - 1477-0539

VL - 15

SP - 7758

EP - 7764

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 37

ER -

Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction

Abstract

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