TY - JOUR
T1 - Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction
AU - Llona-Minguez, Sabin
AU - Throup, Adam
AU - Steiner, Emilie
AU - Lightowler, Molly
AU - Van der Haegen, Sandra
AU - Homan, Evert
AU - Eriksson, Lars
AU - Stenmark, Pål
AU - Jenmalm-Jensen, Annika
AU - Helleday, Thomas
PY - 2017/9/26
Y1 - 2017/9/26
N2 - Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.
AB - Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.
UR - https://www.scopus.com/pages/publications/85030222551
U2 - 10.1039/c7ob02069d
DO - 10.1039/c7ob02069d
M3 - Article
C2 - 28891572
SN - 1477-0539
VL - 15
SP - 7758
EP - 7764
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 37
ER -