Novel strategies for the treatment of grass pollen-induced allergic rhinitis

Olivia Larsson, Laila Hellkvist, Ulla Peterson-Westin, Lars Olaf Cardell

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Allergic rhinitis (AR) affects over 20% of the population of Europe and the United States. Allergen immunotherapy (AIT) is currently the only form of treatment that affects symptoms and modifies the progression of disease. Established forms of AIT include subcutaneous (SCIT) and sublingual (SLIT) immunotherapy and are widely effective, yet only 2-9% of eligible patients undergo therapy, likely due to the long duration of treatment. As a result, novel, faster forms of AIT are currently under development. Areas covered: This article provides an overview of AR and summarises the efficacy and mechanisms of established forms of AIT, highlighting the current drawbacks. We discuss novel strategies of AIT that have been developed in an attempt to tackle these limitations, including epicutaneous, intradermal and intralymphatic immunotherapy (ILIT), focusing on ILIT, the treatment that has been most comprehensively assessed. Expert opinion: Current strategies to treat AR suffer from a poor safety profile and, importantly, lack of adherence. ILIT is a faster and safer form of AIT, with a treatment regime of only 12 weeks. Further validation is required, but ILIT, with its short and comparatively inexpensive protocol, has the potential to offer disease-modifying therapy to a larger number of patients.

Original languageEnglish
Pages (from-to)1143-1150
Number of pages8
JournalExpert Opinion on Biological Therapy
Volume16
Issue number9
DOIs
Publication statusPublished - 2016 Sept 1

Subject classification (UKÄ)

  • Respiratory Medicine and Allergy
  • Immunology in the medical area

Free keywords

  • allergen immunotherapy
  • Allergic rhinitis
  • allergy
  • grass pollen
  • intralymphatic immunotherapy

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