Abstract
Thrombotic microangiopathy can be caused by several conditions which are difficult to diagnose from the clinical presentation alone. Deficient enzyme activity of a newly-discovered enzyme, ADAMTS-13, can lead to thrombotic thrombocytopenic purpura (TTP). Lack of ADAMTS-13 activity causes increased concentrations of high molecular weight von Willebrand factor forms and increased platelet aggregation. Measurement of ADAMTS-13 activity is useful for the diagnosis of TTP and may also be relevant as a prognostic test for recurrent TTP.
| Translated title of the contribution | New marker in thrombotic thrombocytopenic purpura |
|---|---|
| Original language | Danish |
| Pages (from-to) | 2446-9 |
| Number of pages | 4 |
| Journal | Ugeskrift for Laeger |
| Volume | 170 |
| Issue number | 33 |
| Publication status | Published - 2008 Aug 11 |
Subject classification (UKÄ)
- Medicinal Chemistry
- Biological Sciences
Free keywords
- ADAM Proteins/blood
- ADAMTS13 Protein
- Biomarkers/blood
- Diagnosis, Differential
- Humans
- Purpura, Thrombotic Thrombocytopenic/blood
- von Willebrand Factor/genetics