OARSI/OMERACT Criteria of Being Considered a Candidate for Total Joint Replacement in Knee/Hip Osteoarthritis as an Endpoint in Clinical Trials Evaluating Potential Disease Modifying Osteoarthritic Drugs

Maxime Dougados, Gillian Hawker, Stefan Lohmander, Aileen M. Davis, Paul Dieppe, Jean-Francis Maillefert, Laure Gossec

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

Abstract

Objective. A disease-modifying osteoarthritic drug (DMOAD) should interfere with the cartilage breakdown observed and improve symptoms or prevent deterioration of the patient's clinical condition. We propose a composite index including structural and symptomatic variables of osteoarthritis (OA) as criteria for being considered a candidate for total joint replacement as an endpoint in clinical trials evaluating potential DMOAD. Methods. An OARSI/OMERACT task force conducted this study in 3 steps: (1) The 3 main domains - pain, function, structure - were revisited; (2) For each of the domains a "non-acceptable state" and a "relevant" progression for their structure were defined; and (3) a set of criteria was proposed combining the information from these 3 domains. Results. A questionnaire was elaborated for the domains "pain" and "function." Systematic research of the literature and evaluation of different databases concluded that the domain "structure" should be evaluated by radiological joint space width in millimeters. An unacceptable radiographic progression was defined as a change in the joint space width over the measurement error. An international, cross-sectional study is proposing a definition of a "nonacceptable symptom state." Conclusion. The objective of the ongoing OARSI/OMERACT initiative is to propose criteria for being considered a candidate for total joint replacement to be used as an endpoint in clinical trials evaluating potential DMOAD. The preliminary steps of this initiative have been completed. (J Rheumatol 2009;36:2097-9; doi:10.3899/jrheum.090365)
Original languageEnglish
Title of host publicationJournal of Rheumatology
PublisherJournal of Rheumatology Publishing Company Limited
Pages2097-2099
Volume36
DOIs
Publication statusPublished - 2009
Event9th International Consensus Conference on Outcome Measures in Rheumatology Clinical Trails (OMERACT 9) - Kananaskis, Canada
Duration: 2008 May 272008 May 31

Publication series

Name
Number9
Volume36
ISSN (Print)0315-162X
ISSN (Electronic)1499-2752

Conference

Conference9th International Consensus Conference on Outcome Measures in Rheumatology Clinical Trails (OMERACT 9)
Country/TerritoryCanada
CityKananaskis
Period2008/05/272008/05/31

Subject classification (UKÄ)

  • Rheumatology and Autoimmunity

Free keywords

  • ANTI-OSTEOARTHRITIC DRUGS
  • OSTEOARTHRITIS
  • TOTAL JOINT REPLACEMENT

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