On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture

Tania Lind, Piotr Polcyn, Paulina Zielinska, Marite Cardenas, Zofia Urbanczyk-Lipkowska

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and amphiphilicity, rather than net charge, is the main driver for disruption of cellular membranes and this correlates well with dendrimer hemolytic activity.
    Original languageEnglish
    Pages (from-to)738-753
    JournalMolecules
    Volume20
    Issue number1
    DOIs
    Publication statusPublished - 2015

    Subject classification (UKÄ)

    • Natural Sciences
    • Physical Sciences

    Free keywords

    • dendrimers
    • peptide
    • antimicrobial
    • lipids

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