2 Citations (SciVal)

Abstract

Jassinskaja et al. describe ontogeny-specific proteomic signatures and functionality of lineage-biased hematopoietic progenitor cells (HPCs). They uncover that fetal-specific features differ between lymphoid-competent and myeloid-restricted progenitors and reveal an ontogenic shift in monocyte differentiation capacity, partially driven by differential Irf8 expression between fetal and adult granulocyte-monocyte progenitors (GMPs).

Original languageEnglish
Article number108894
JournalCell Reports
Volume34
Issue number12
DOIs
Publication statusPublished - 2021

Subject classification (UKÄ)

  • Hematology

Keywords

  • adult hematopoiesis
  • developmental hematopoiesis
  • fetal hematopoiesis
  • hematopoietic progenitor cells
  • Irf8
  • lymphopoiesis
  • myelopoiesis
  • proteomics

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