Optimization of PIXE-sensitivity for detection of Ti in thin human skin sections

Jan Pallon, Mats Garmer, Vaida Auzelyte, Mikael Elfman, Per Kristiansson, Klas Malmqvist, Christer Nilsson, Asad Shariff, Marie Wegdén

    Research output: Contribution to journalArticlepeer-review


    Modern sunscreens contain particles like TiO2 having sizes of 25-70 nm and acting as a reflecting substance. For cosmetic reasons the particle size is minimized. Questions have been raised to what degree these nano particles penetrate the skin barrier, and how they do affect the human. The EU funded project "Quality of skin as a barrier to ultra-fine particles" - NANODERM has started with the purpose to evaluate the possible risks of TiO2 penetration into vital skin layers. The purpose of the work presented here was to find the optimal conditions for micro-PIXE analysis of Ti in thin skin sections. In the skin region where Ti is expected to be found, the naturally occurring major elements phosphorus, chlorine, sulphur and potassium have steep gradients and thus influence the X-ray background in a non-predictable manner. Based on experimental studies of Ti-exposed human skin sections using proton energies ranging from 1.8-2.55 MeV, the corresponding PIXE detection limits for Ti were calculated. The energy that was found to be the most favourable, 1.9 MeV, was then selected for future studies.
    Original languageEnglish
    Pages (from-to)274-279
    JournalNuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
    Issue number1-4
    Publication statusPublished - 2005

    Bibliographical note

    The information about affiliations in this record was updated in December 2015.
    The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007)

    Subject classification (UKÄ)

    • Subatomic Physics

    Free keywords

    • skin
    • nuclear microprobe
    • PIXE
    • detection limits


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