Abstract
The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.
| Original language | English |
|---|---|
| Pages (from-to) | 1063-1067 |
| Journal | Drug Development and Industrial Pharmacy |
| Volume | 13 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1987 |
Subject classification (UKÄ)
- Probability Theory and Statistics