Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

K. K. Tsilidis; N. E. Allen; T. J. Key; K. Bakken; E. Lund; F. Berrino; A. Fournier; A. Olsen; A. Tjonneland; K. Overvad; M-C Boutron-Ruault; F. Clavel-Chapelon; G. Byrnes; V. Chajes; S. Rinaldi; J. Chang-Claude; R. Kaaks; M. Bergmann; H. Boeing; Y. Koumantaki; G. Stasinopoulou; A. Trichopoulou; D. Palli; G. Tagliabue; S. Panico; R. Tumino; P. Vineis; H. B. Bueno-de-Mesquita; F. J. B. van Duijnhoven; C. H. van Gils; P. H. M. Peeters; L. Rodriguez; C. A. Gonzalez; M-J Sanchez; M-D Chirlaque; A. Barricarte; M. Dorronsoro; Signe Borgquist; Jonas Manjer; B. van Guelpen; G. Hallmans; S. A. Rodwell; K-T Khaw; T. Norat; D. Romaguera; E. Riboli

doi:10.1038/sj.bjc.6605965

Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

K. K. Tsilidis, N. E. Allen, T. J. Key, K. Bakken, E. Lund, F. Berrino, A. Fournier, A. Olsen, A. Tjonneland, K. Overvad, M-C Boutron-Ruault, F. Clavel-Chapelon, G. Byrnes, V. Chajes, S. Rinaldi, J. Chang-Claude, R. Kaaks, M. Bergmann, H. Boeing, Y. KoumantakiG. Stasinopoulou, A. Trichopoulou, D. Palli, G. Tagliabue, S. Panico, R. Tumino, P. Vineis, H. B. Bueno-de-Mesquita, F. J. B. van Duijnhoven, C. H. van Gils, P. H. M. Peeters, L. Rodriguez, C. A. Gonzalez, M-J Sanchez, M-D Chirlaque, A. Barricarte, M. Dorronsoro, Signe Borgquist, Jonas Manjer, B. van Guelpen, G. Hallmans, S. A. Rodwell, K-T Khaw, T. Norat, D. Romaguera, E. Riboli

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk. METHODS: We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337 802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer. RESULTS: After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk. CONCLUSION: Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk. British Journal of Cancer (2010) 103, 1755-1759. doi:10.1038/sj.bjc.6605965 www.bjcancer.com Published online 2 November 2010 (C) 2010 Cancer Research UK

Original language	English
Pages (from-to)	1755-1759
Journal	British Journal of Cancer
Volume	103
Issue number	11
DOIs	https://doi.org/10.1038/sj.bjc.6605965
Publication status	Published - 2010

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

cohort
colorectal cancer
oral contraceptives
reproductive history
study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6605965

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Tsilidis, K. K., Allen, N. E., Key, T. J., Bakken, K., Lund, E., Berrino, F., Fournier, A., Olsen, A., Tjonneland, A., Overvad, K., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Byrnes, G., Chajes, V., Rinaldi, S., Chang-Claude, J., Kaaks, R., Bergmann, M., Boeing, H., ... Riboli, E. (2010). Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition. British Journal of Cancer, 103(11), 1755-1759. https://doi.org/10.1038/sj.bjc.6605965

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title = "Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition",

abstract = "BACKGROUND: Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk. METHODS: We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337 802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer. RESULTS: After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk. CONCLUSION: Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk. British Journal of Cancer (2010) 103, 1755-1759. doi:10.1038/sj.bjc.6605965 www.bjcancer.com Published online 2 November 2010 (C) 2010 Cancer Research UK",

keywords = "cohort, colorectal cancer, oral contraceptives, reproductive history, study",

author = "Tsilidis, {K. K.} and Allen, {N. E.} and Key, {T. J.} and K. Bakken and E. Lund and F. Berrino and A. Fournier and A. Olsen and A. Tjonneland and K. Overvad and M-C Boutron-Ruault and F. Clavel-Chapelon and G. Byrnes and V. Chajes and S. Rinaldi and J. Chang-Claude and R. Kaaks and M. Bergmann and H. Boeing and Y. Koumantaki and G. Stasinopoulou and A. Trichopoulou and D. Palli and G. Tagliabue and S. Panico and R. Tumino and P. Vineis and Bueno-de-Mesquita, {H. B.} and {van Duijnhoven}, {F. J. B.} and {van Gils}, {C. H.} and Peeters, {P. H. M.} and L. Rodriguez and Gonzalez, {C. A.} and M-J Sanchez and M-D Chirlaque and A. Barricarte and M. Dorronsoro and Signe Borgquist and Jonas Manjer and {van Guelpen}, B. and G. Hallmans and Rodwell, {S. A.} and K-T Khaw and T. Norat and D. Romaguera and E. Riboli",

year = "2010",

doi = "10.1038/sj.bjc.6605965",

language = "English",

volume = "103",

pages = "1755--1759",

journal = "British Journal of Cancer",

issn = "1532-1827",

publisher = "Nature Publishing Group",

number = "11",

}

Tsilidis, KK, Allen, NE, Key, TJ, Bakken, K, Lund, E, Berrino, F, Fournier, A, Olsen, A, Tjonneland, A, Overvad, K, Boutron-Ruault, M-C, Clavel-Chapelon, F, Byrnes, G, Chajes, V, Rinaldi, S, Chang-Claude, J, Kaaks, R, Bergmann, M, Boeing, H, Koumantaki, Y, Stasinopoulou, G, Trichopoulou, A, Palli, D, Tagliabue, G, Panico, S, Tumino, R, Vineis, P, Bueno-de-Mesquita, HB, van Duijnhoven, FJB, van Gils, CH, Peeters, PHM, Rodriguez, L, Gonzalez, CA, Sanchez, M-J, Chirlaque, M-D, Barricarte, A, Dorronsoro, M, Borgquist, S , Manjer, J, van Guelpen, B, Hallmans, G, Rodwell, SA, Khaw, K-T, Norat, T, Romaguera, D & Riboli, E 2010, 'Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition', British Journal of Cancer, vol. 103, no. 11, pp. 1755-1759. https://doi.org/10.1038/sj.bjc.6605965

TY - JOUR

T1 - Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

AU - Tsilidis, K. K.

AU - Allen, N. E.

AU - Key, T. J.

AU - Bakken, K.

AU - Lund, E.

AU - Berrino, F.

AU - Fournier, A.

AU - Olsen, A.

AU - Tjonneland, A.

AU - Overvad, K.

AU - Boutron-Ruault, M-C

AU - Clavel-Chapelon, F.

AU - Byrnes, G.

AU - Chajes, V.

AU - Rinaldi, S.

AU - Chang-Claude, J.

AU - Kaaks, R.

AU - Bergmann, M.

AU - Boeing, H.

AU - Koumantaki, Y.

AU - Stasinopoulou, G.

AU - Trichopoulou, A.

AU - Palli, D.

AU - Tagliabue, G.

AU - Panico, S.

AU - Tumino, R.

AU - Vineis, P.

AU - Bueno-de-Mesquita, H. B.

AU - van Duijnhoven, F. J. B.

AU - van Gils, C. H.

AU - Peeters, P. H. M.

AU - Rodriguez, L.

AU - Gonzalez, C. A.

AU - Sanchez, M-J

AU - Chirlaque, M-D

AU - Barricarte, A.

AU - Dorronsoro, M.

AU - Borgquist, Signe

AU - Manjer, Jonas

AU - van Guelpen, B.

AU - Hallmans, G.

AU - Rodwell, S. A.

AU - Khaw, K-T

AU - Norat, T.

AU - Romaguera, D.

AU - Riboli, E.

PY - 2010

Y1 - 2010

N2 - BACKGROUND: Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk. METHODS: We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337 802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer. RESULTS: After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk. CONCLUSION: Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk. British Journal of Cancer (2010) 103, 1755-1759. doi:10.1038/sj.bjc.6605965 www.bjcancer.com Published online 2 November 2010 (C) 2010 Cancer Research UK

AB - BACKGROUND: Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk. METHODS: We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337 802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer. RESULTS: After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk. CONCLUSION: Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk. British Journal of Cancer (2010) 103, 1755-1759. doi:10.1038/sj.bjc.6605965 www.bjcancer.com Published online 2 November 2010 (C) 2010 Cancer Research UK

KW - cohort

KW - colorectal cancer

KW - oral contraceptives

KW - reproductive history

KW - study

U2 - 10.1038/sj.bjc.6605965

DO - 10.1038/sj.bjc.6605965

M3 - Article

C2 - 21045829

SN - 1532-1827

VL - 103

SP - 1755

EP - 1759

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 11

ER -

Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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