Oscillations in cortico-basal ganglia circuits: implications for Parkinson's disease and other neurologic and psychiatric conditions

Pär Halje, Ivani Brys, Juan J. Mariman, Claudio da Cunha, Romulo Fuentes, Per Petersson

Research output: Contribution to journalReview articlepeer-review

11 Citations (SciVal)

Abstract

Cortico-basal ganglia circuits are thought to play a crucial role in the selection and control of motor behaviors and have also been implicated in the processing of motivational content and in higher cognitive functions. During the last two decades, electrophysiological recordings in basal ganglia circuits have shown that several disease conditions are associated with specific changes in the temporal patterns of neuronal activity. In particular, synchronized oscillations have been a frequent finding suggesting that excessive synchronization of neuronal activity may be a pathophysiological mechanism involved in a wide range of neurologic and psychiatric conditions. We here review the experimental support for this hypothesis primarily in relation to Parkinson's disease but also in relation to dystonia, essential tremor, epilepsy, and psychosis/schizophrenia.

Original languageEnglish
Pages (from-to)203-231
Number of pages29
JournalJournal of Neurophysiology
Volume122
Issue number1
DOIs
Publication statusPublished - 2019 Jul

Subject classification (UKÄ)

  • Neurosciences
  • Psychology (excluding Applied Psychology)

Keywords

  • integrative neurophysiology
  • synchrony
  • systems level

Fingerprint

Dive into the research topics of 'Oscillations in cortico-basal ganglia circuits: implications for Parkinson's disease and other neurologic and psychiatric conditions'. Together they form a unique fingerprint.

Cite this