Osteoarthritis development related to cartilage quality-the prognostic value of dGEMRIC after anterior cruciate ligament injury

Jon Tjörnstrand; Paul Neuman; Jonas Svensson; Björn Lundin; Leif Dahlberg; Carl Johan Tiderius

doi:10.1016/j.joca.2019.06.012

Osteoarthritis development related to cartilage quality-the prognostic value of dGEMRIC after anterior cruciate ligament injury

Jon Tjörnstrand, Paul Neuman, Jonas Svensson, Björn Lundin, Leif Dahlberg, Carl Johan Tiderius

Skåne University Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

Objective
Rupture of the anterior cruciate ligament (ACL) increases the risk of developing osteoarthritis (OA). Delayed Gadolinium enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) investigates cartilage integrity through T1-analysis after intravenous contrast injection. A high dGEMRIC index represents good cartilage quality. The main purpose of this prospective cohort study was to investigate the prognostic value of the dGEMRIC index regarding future knee OA.
Method
31 patients with ACL injury (mean age 27 ± 6.7 (±SD) years, 19 males) were examined after 2 years with 1.5T dGEMRIC of femoral cartilage. Re-examination 14 years post-injury included weight-bearing knee radiographs, Lysholm and Knee Osteoarthritis Outcome Score (KOOS).
Results
At the 14-year follow up radiographic OA (ROA) was present in 68% and OA symptoms (SOA) in 42% of the injured knees. The dGEMRIC index of the medial compartment was lower in knees that developed medial ROA, 325 ± 68 (ms±SD) vs 376 ± 47 (51 (7–94)) (difference of means (95% confidence interval (CI))), in patients that developed symptomatic OA (SOA), 327 ± 61 vs 399 ± 42 (52 (11–93)), and poor knee function 337 ± 54 vs 381 ± 52 (48 (7–89)) compared to those that did not develop ROA, SOA or poor function. The dGEMRIC index correlated negatively with the OARSI osteophyte score in medial (r = −0.44, P = 0.01) and lateral (r = −0.38, P = 0.03) compartments.
Conclusion
The associations between a low dGEMRIC index and future ROA, as well as SOA, are in agreement with previous studies and indicate that dGEMRIC has a prognostic value for future knee OA.

Original language	English
Pages (from-to)	1647-1652
Journal	Osteoarthritis and Cartilage
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/j.joca.2019.06.012
Publication status	Published - 2019 Jun 13

Subject classification (UKÄ)

Orthopedics
Radiology, Nuclear Medicine and Medical Imaging

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10.1016/j.joca.2019.06.012

1 Doctoral Thesis (compilation)

The prognostic value of dGEMRIC regarding future knee OA Long-term assessment after traumatic chondral injury and ACL injury
Tjörnstrand, J., 2019, Lund: Lund University: Faculty of Medicine. 120 p.
Research output: Thesis › Doctoral Thesis (compilation)

Open Access
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@article{18c87b9d79b042bdb80ae9f8c44b60d2,

title = "Osteoarthritis development related to cartilage quality-the prognostic value of dGEMRIC after anterior cruciate ligament injury",

abstract = "ObjectiveRupture of the anterior cruciate ligament (ACL) increases the risk of developing osteoarthritis (OA). Delayed Gadolinium enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) investigates cartilage integrity through T1-analysis after intravenous contrast injection. A high dGEMRIC index represents good cartilage quality. The main purpose of this prospective cohort study was to investigate the prognostic value of the dGEMRIC index regarding future knee OA.Method31 patients with ACL injury (mean age 27 ± 6.7 (±SD) years, 19 males) were examined after 2 years with 1.5T dGEMRIC of femoral cartilage. Re-examination 14 years post-injury included weight-bearing knee radiographs, Lysholm and Knee Osteoarthritis Outcome Score (KOOS).ResultsAt the 14-year follow up radiographic OA (ROA) was present in 68% and OA symptoms (SOA) in 42% of the injured knees. The dGEMRIC index of the medial compartment was lower in knees that developed medial ROA, 325 ± 68 (ms±SD) vs 376 ± 47 (51 (7–94)) (difference of means (95% confidence interval (CI))), in patients that developed symptomatic OA (SOA), 327 ± 61 vs 399 ± 42 (52 (11–93)), and poor knee function 337 ± 54 vs 381 ± 52 (48 (7–89)) compared to those that did not develop ROA, SOA or poor function. The dGEMRIC index correlated negatively with the OARSI osteophyte score in medial (r = −0.44, P = 0.01) and lateral (r = −0.38, P = 0.03) compartments.ConclusionThe associations between a low dGEMRIC index and future ROA, as well as SOA, are in agreement with previous studies and indicate that dGEMRIC has a prognostic value for future knee OA.",

author = "Jon Tj{\"o}rnstrand and Paul Neuman and Jonas Svensson and Bj{\"o}rn Lundin and Leif Dahlberg and Tiderius, {Carl Johan}",

year = "2019",

month = jun,

day = "13",

doi = "10.1016/j.joca.2019.06.012",

language = "English",

volume = "27",

pages = "1647--1652",

journal = "Osteoarthritis and Cartilage",

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T1 - Osteoarthritis development related to cartilage quality-the prognostic value of dGEMRIC after anterior cruciate ligament injury

AU - Tjörnstrand, Jon

AU - Neuman, Paul

AU - Svensson, Jonas

AU - Lundin, Björn

AU - Dahlberg, Leif

AU - Tiderius, Carl Johan

PY - 2019/6/13

Y1 - 2019/6/13

N2 - ObjectiveRupture of the anterior cruciate ligament (ACL) increases the risk of developing osteoarthritis (OA). Delayed Gadolinium enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) investigates cartilage integrity through T1-analysis after intravenous contrast injection. A high dGEMRIC index represents good cartilage quality. The main purpose of this prospective cohort study was to investigate the prognostic value of the dGEMRIC index regarding future knee OA.Method31 patients with ACL injury (mean age 27 ± 6.7 (±SD) years, 19 males) were examined after 2 years with 1.5T dGEMRIC of femoral cartilage. Re-examination 14 years post-injury included weight-bearing knee radiographs, Lysholm and Knee Osteoarthritis Outcome Score (KOOS).ResultsAt the 14-year follow up radiographic OA (ROA) was present in 68% and OA symptoms (SOA) in 42% of the injured knees. The dGEMRIC index of the medial compartment was lower in knees that developed medial ROA, 325 ± 68 (ms±SD) vs 376 ± 47 (51 (7–94)) (difference of means (95% confidence interval (CI))), in patients that developed symptomatic OA (SOA), 327 ± 61 vs 399 ± 42 (52 (11–93)), and poor knee function 337 ± 54 vs 381 ± 52 (48 (7–89)) compared to those that did not develop ROA, SOA or poor function. The dGEMRIC index correlated negatively with the OARSI osteophyte score in medial (r = −0.44, P = 0.01) and lateral (r = −0.38, P = 0.03) compartments.ConclusionThe associations between a low dGEMRIC index and future ROA, as well as SOA, are in agreement with previous studies and indicate that dGEMRIC has a prognostic value for future knee OA.

AB - ObjectiveRupture of the anterior cruciate ligament (ACL) increases the risk of developing osteoarthritis (OA). Delayed Gadolinium enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) investigates cartilage integrity through T1-analysis after intravenous contrast injection. A high dGEMRIC index represents good cartilage quality. The main purpose of this prospective cohort study was to investigate the prognostic value of the dGEMRIC index regarding future knee OA.Method31 patients with ACL injury (mean age 27 ± 6.7 (±SD) years, 19 males) were examined after 2 years with 1.5T dGEMRIC of femoral cartilage. Re-examination 14 years post-injury included weight-bearing knee radiographs, Lysholm and Knee Osteoarthritis Outcome Score (KOOS).ResultsAt the 14-year follow up radiographic OA (ROA) was present in 68% and OA symptoms (SOA) in 42% of the injured knees. The dGEMRIC index of the medial compartment was lower in knees that developed medial ROA, 325 ± 68 (ms±SD) vs 376 ± 47 (51 (7–94)) (difference of means (95% confidence interval (CI))), in patients that developed symptomatic OA (SOA), 327 ± 61 vs 399 ± 42 (52 (11–93)), and poor knee function 337 ± 54 vs 381 ± 52 (48 (7–89)) compared to those that did not develop ROA, SOA or poor function. The dGEMRIC index correlated negatively with the OARSI osteophyte score in medial (r = −0.44, P = 0.01) and lateral (r = −0.38, P = 0.03) compartments.ConclusionThe associations between a low dGEMRIC index and future ROA, as well as SOA, are in agreement with previous studies and indicate that dGEMRIC has a prognostic value for future knee OA.

U2 - 10.1016/j.joca.2019.06.012

DO - 10.1016/j.joca.2019.06.012

M3 - Article

C2 - 31279937

SN - 1063-4584

VL - 27

SP - 1647

EP - 1652

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 11

ER -

Osteoarthritis development related to cartilage quality-the prognostic value of dGEMRIC after anterior cruciate ligament injury

Abstract

Subject classification (UKÄ)

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Research output

The prognostic value of dGEMRIC regarding future knee OA Long-term assessment after traumatic chondral injury and ACL injury

Cite this