Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.

Anele Gela; Gopinath Kasetty; Matthias Mörgelin; Anders Bergqvist; Jonas Erjefält; James E Pease; Arne Egesten

doi:10.1111/all.12771

Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.

Anele Gela, Gopinath Kasetty, Matthias Mörgelin, Anders Bergqvist, Jonas Erjefält, James E Pease, Arne Egesten

Research output: Contribution to journal › Article › peer-review

Abstract

Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28. In addition to inducing chemotaxis, several of these molecules have defensin-like antibacterial properties. This study set out to elucidate the functional consequences of OPN-binding to eosinophil-recruiting chemokines.

Original language	English
Pages (from-to)	58-67
Journal	Allergy
Volume	71
Issue number	1
DOIs	https://doi.org/10.1111/all.12771
Publication status	Published - 2016

Subject classification (UKÄ)

Respiratory Medicine and Allergy

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10.1111/all.12771

http://www.ncbi.nlm.nih.gov/pubmed/26411293?dopt=Abstract

1 Doctoral Thesis (compilation)

On airway host defence during allergic inflammation
Gela, A., 2016, Lund: Lund University: Faculty of Medicine. 64 p.
Research output: Thesis › Doctoral Thesis (compilation)

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title = "Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.",

abstract = "Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28. In addition to inducing chemotaxis, several of these molecules have defensin-like antibacterial properties. This study set out to elucidate the functional consequences of OPN-binding to eosinophil-recruiting chemokines.",

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year = "2016",

doi = "10.1111/all.12771",

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volume = "71",

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journal = "Allergy",

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T1 - Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.

AU - Gela, Anele

AU - Kasetty, Gopinath

AU - Mörgelin, Matthias

AU - Bergqvist, Anders

AU - Erjefält, Jonas

AU - Pease, James E

AU - Egesten, Arne

PY - 2016

Y1 - 2016

N2 - Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28. In addition to inducing chemotaxis, several of these molecules have defensin-like antibacterial properties. This study set out to elucidate the functional consequences of OPN-binding to eosinophil-recruiting chemokines.

AB - Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28. In addition to inducing chemotaxis, several of these molecules have defensin-like antibacterial properties. This study set out to elucidate the functional consequences of OPN-binding to eosinophil-recruiting chemokines.

U2 - 10.1111/all.12771

DO - 10.1111/all.12771

M3 - Article

C2 - 26411293

SN - 1398-9995

VL - 71

SP - 58

EP - 67

JO - Allergy

JF - Allergy

IS - 1

ER -

Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.

Abstract

Subject classification (UKÄ)

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Research output

On airway host defence during allergic inflammation

Cite this