Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis.

Hope E Uronis; Magnus Ekström; David C Currow; Douglas C McCrory; Gregory P Samsa; Amy P Abernethy

doi:10.1136/thoraxjnl-2014-205720

Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis.

Hope E Uronis, Magnus Ekström, David C Currow, Douglas C McCrory, Gregory P Samsa, Amy P Abernethy

Research output: Contribution to journal › Article › peer-review

Abstract

We searched MEDLINE, EMBASE and the Cochrane Controlled Trials Register to determine whether oxygen relieves dyspnoea in mildly or non-hypoxemic COPD and included 18 randomised controlled trials (431 participants) in the meta-analysis using Cochrane methodology. Oxygen therapy reduced dyspnoea when compared with medical air; standardised mean difference -0.37 (95% CI -0.50 to -0.24; I(2)=14%). In a priori subgroup and sensitivity analyses, dyspnoea was reduced by continuous oxygen during exertion but not short-burst oxygen therapy. Continuous exertional oxygen can relieve dyspnoea in mildly or non-hypoxemic COPD, but evidence from larger clinical trials is needed.

Original language	English
Pages (from-to)	492-494
Journal	Thorax
Volume	70
Issue number	5
DOIs	https://doi.org/10.1136/thoraxjnl-2014-205720
Publication status	Published - 2015

Subject classification (UKÄ)

Respiratory Medicine and Allergy

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10.1136/thoraxjnl-2014-205720

http://www.ncbi.nlm.nih.gov/pubmed/25472664?dopt=Abstract

Cite this

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title = "Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis.",

abstract = "We searched MEDLINE, EMBASE and the Cochrane Controlled Trials Register to determine whether oxygen relieves dyspnoea in mildly or non-hypoxemic COPD and included 18 randomised controlled trials (431 participants) in the meta-analysis using Cochrane methodology. Oxygen therapy reduced dyspnoea when compared with medical air; standardised mean difference -0.37 (95\% CI -0.50 to -0.24; I(2)=14\%). In a priori subgroup and sensitivity analyses, dyspnoea was reduced by continuous oxygen during exertion but not short-burst oxygen therapy. Continuous exertional oxygen can relieve dyspnoea in mildly or non-hypoxemic COPD, but evidence from larger clinical trials is needed.",

author = "Uronis, \{Hope E\} and Magnus Ekstr{\"o}m and Currow, \{David C\} and McCrory, \{Douglas C\} and Samsa, \{Gregory P\} and Abernethy, \{Amy P\}",

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AU - Uronis, Hope E

AU - Ekström, Magnus

AU - Currow, David C

AU - McCrory, Douglas C

AU - Samsa, Gregory P

AU - Abernethy, Amy P

PY - 2015

Y1 - 2015

N2 - We searched MEDLINE, EMBASE and the Cochrane Controlled Trials Register to determine whether oxygen relieves dyspnoea in mildly or non-hypoxemic COPD and included 18 randomised controlled trials (431 participants) in the meta-analysis using Cochrane methodology. Oxygen therapy reduced dyspnoea when compared with medical air; standardised mean difference -0.37 (95% CI -0.50 to -0.24; I(2)=14%). In a priori subgroup and sensitivity analyses, dyspnoea was reduced by continuous oxygen during exertion but not short-burst oxygen therapy. Continuous exertional oxygen can relieve dyspnoea in mildly or non-hypoxemic COPD, but evidence from larger clinical trials is needed.

AB - We searched MEDLINE, EMBASE and the Cochrane Controlled Trials Register to determine whether oxygen relieves dyspnoea in mildly or non-hypoxemic COPD and included 18 randomised controlled trials (431 participants) in the meta-analysis using Cochrane methodology. Oxygen therapy reduced dyspnoea when compared with medical air; standardised mean difference -0.37 (95% CI -0.50 to -0.24; I(2)=14%). In a priori subgroup and sensitivity analyses, dyspnoea was reduced by continuous oxygen during exertion but not short-burst oxygen therapy. Continuous exertional oxygen can relieve dyspnoea in mildly or non-hypoxemic COPD, but evidence from larger clinical trials is needed.

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U2 - 10.1136/thoraxjnl-2014-205720

DO - 10.1136/thoraxjnl-2014-205720

M3 - Article

C2 - 25472664

SN - 1468-3296

VL - 70

SP - 492

EP - 494

JO - Thorax

JF - Thorax

IS - 5

ER -

Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis.

Abstract

Subject classification (UKÄ)

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