Oxytocin receptor mimetics were prepared by molecular imprinting using Z-oxytocin as the template. Comparative binding studies with reference polymers showed that the imprinted polymers recognized both Z-oxytocin and unprotected oxytocin selectively. The dissociation constants were 47 µM and 102 µM,respectively, and the density of binding sites was 12 µmol/g. The synthetic oxytocin receptors were easily prepared, possessed high mechanical and chemical stability, and were reused without loss of selectivity and capacity after regeneration by extraction.
Bibliographical noteThe information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Biomedical Polymer Technology (013212010)
Subject classification (UKÄ)
- Organic Chemistry