Oxytocin receptor mimetics prepared by molecular imprinting.

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9 Citations (Scopus)

Abstract

Oxytocin receptor mimetics were prepared by molecular imprinting using Z-oxytocin as the template. Comparative binding studies with reference polymers showed that the imprinted polymers recognized both Z-oxytocin and unprotected oxytocin selectively. The dissociation constants were 47 µM and 102 µM,respectively, and the density of binding sites was 12 µmol/g. The synthetic oxytocin receptors were easily prepared, possessed high mechanical and chemical stability, and were reused without loss of selectivity and capacity after regeneration by extraction.
Original languageEnglish
Pages (from-to)27-33
JournalLetters in Peptide Science
Volume7
Issue number1
DOIs
Publication statusPublished - 2000

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Biomedical Polymer Technology (013212010)

Subject classification (UKÄ)

  • Organic Chemistry

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