P-Coumaric Acid Mitigates Doxorubicin-Induced Nephrotoxicity Through Suppression of Oxidative Stress, Inflammation and Apoptosis

Zeinab Rafiee, Maasoumeh Zare Moaiedi, Armita Valizade Gorji, Esrafil Mansouri

Research output: Contribution to journalArticlepeer-review

22 Citations (SciVal)

Abstract

Background and Aims
P-Coumaric acid (PCA) is one the compound that has free radical scavenging effects. This study investigates the protective effect of PCA on tissue damage in DOX-induced nephrotoxicity.

Methods
Thirty two Wistar rats were divided into control, PCA, DOX (15 mg/kg, i.p.) and DOX plus PCA (100 mg/kg, orally) groups. DOX-induced nephrotoxicity was indicated by marked increase in blood urea nitrogen (BUN) and serum creatinine (Cr) compared to controls. DOX group also showed elevations in lipid peroxidation and reductions in enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT). Expression of renal inflammatory cytokines including tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) and apoptosis were also elevated in the DOX group.

Results
PCA significantly reversed, nephrotoxicity induced by DOX via lowering BUN, serum Cr and improving histopathological scores as compared to the DOX group. PCA also decreased lipid peroxidation, increased activities of GPx, SOD and CAT, to levels relatively comparable to control. Significant reductions in expression of TNF-α, IL-1β and apoptosis were also observed following Co-administration of PCA relative to the DOX group.

Conclusions
Results describe a protective effect of PCA against DOX-induced nephrotoxicity. This effect is likely facilitated through inhibition of oxidative stress, inflammation and apoptosis.
Original languageEnglish
Pages (from-to)32-40
JournalArchives of Medical Research
Volume51
Issue number1
DOIs
Publication statusPublished - 2020 Jan 1
Externally publishedYes

Subject classification (UKÄ)

  • Pharmacology and Toxicology
  • Physiology

Keywords

  • Doxorubicin
  • Nephrotoxicity
  • p-Coumaric acid
  • Oxidative stress
  • inflammatory markers
  • Apoptosis

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