P57Kip2regulates T-cell development and lymphoma

Senthil Raja Jayapal; Philipp Kaldis

doi:10.1182/blood-2014-04-565309

P57^Kip2regulates T-cell development and lymphoma

Senthil Raja Jayapal, Philipp Kaldis

Research output: Contribution to journal › Review article › peer-review

Abstract

In this issue of Blood, Matsumoto et al report that T cell-specific deletion of the cyclin-dependent kinase inhibitor p57^Kip2(p57) in mice leads to a block in T-cell development as a result of hyperactivation of the E2F-p53 pathway and demonstrate that the loss of p57 accelerates lymphomagenesis in the absence of p53.

Original language	English
Pages (from-to)	3370-3371
Journal	Blood
Volume	123
Issue number	22
DOIs	https://doi.org/10.1182/blood-2014-04-565309
Publication status	Published - 2014 May 29
Externally published	Yes

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10.1182/blood-2014-04-565309

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@article{190df657a11d42fab661ae00ed9cc991,

title = "P57Kip2regulates T-cell development and lymphoma",

abstract = "In this issue of Blood, Matsumoto et al report that T cell-specific deletion of the cyclin-dependent kinase inhibitor p57Kip2(p57) in mice leads to a block in T-cell development as a result of hyperactivation of the E2F-p53 pathway and demonstrate that the loss of p57 accelerates lymphomagenesis in the absence of p53.",

author = "Jayapal, {Senthil Raja} and Philipp Kaldis",

year = "2014",

month = may,

day = "29",

doi = "10.1182/blood-2014-04-565309",

language = "English",

volume = "123",

pages = "3370--3371",

journal = "Blood",

issn = "1528-0020",

publisher = "American Society of Hematology",

number = "22",

}

TY - JOUR

T1 - P57Kip2regulates T-cell development and lymphoma

AU - Jayapal, Senthil Raja

AU - Kaldis, Philipp

PY - 2014/5/29

Y1 - 2014/5/29

N2 - In this issue of Blood, Matsumoto et al report that T cell-specific deletion of the cyclin-dependent kinase inhibitor p57Kip2(p57) in mice leads to a block in T-cell development as a result of hyperactivation of the E2F-p53 pathway and demonstrate that the loss of p57 accelerates lymphomagenesis in the absence of p53.

AB - In this issue of Blood, Matsumoto et al report that T cell-specific deletion of the cyclin-dependent kinase inhibitor p57Kip2(p57) in mice leads to a block in T-cell development as a result of hyperactivation of the E2F-p53 pathway and demonstrate that the loss of p57 accelerates lymphomagenesis in the absence of p53.

U2 - 10.1182/blood-2014-04-565309

DO - 10.1182/blood-2014-04-565309

M3 - Review article

C2 - 24876523

AN - SCOPUS:84901699631

VL - 123

SP - 3370

EP - 3371

JO - Blood

JF - Blood

SN - 1528-0020

IS - 22

ER -

P57Kip2regulates T-cell development and lymphoma

Abstract

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P57^Kip2regulates T-cell development and lymphoma