P57Kip2regulates T-cell development and lymphoma

Senthil Raja Jayapal, Philipp Kaldis

Research output: Contribution to journalReview articlepeer-review


In this issue of Blood, Matsumoto et al report that T cell-specific deletion of the cyclin-dependent kinase inhibitor p57Kip2(p57) in mice leads to a block in T-cell development as a result of hyperactivation of the E2F-p53 pathway and demonstrate that the loss of p57 accelerates lymphomagenesis in the absence of p53.

Original languageEnglish
Pages (from-to)3370-3371
Issue number22
Publication statusPublished - 2014 May 29
Externally publishedYes


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