Pancreatic cancer is suppressed by fibroblast-derived collagen I

Chris Madsen

doi:10.1016/j.ccell.2021.02.017

Pancreatic cancer is suppressed by fibroblast-derived collagen I

Chris Madsen

Research output: Contribution to journal › Review article › peer-review

Abstract

Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immune
suppression and accelerates progression of disease.

Original language	English
Pages (from-to)	451-453
Number of pages	3
Journal	Cancer Cell
Volume	39
Issue number	4
Early online date	2021 Mar 11
DOIs	https://doi.org/10.1016/j.ccell.2021.02.017
Publication status	Published - 2021 Apr 12

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccell.2021.02.017

Cite this

@article{f29545d8406b445db4e7299d83297182,

title = "Pancreatic cancer is suppressed by fibroblast-derived collagen I",

abstract = "Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immunesuppression and accelerates progression of disease.",

author = "Chris Madsen",

year = "2021",

month = apr,

day = "12",

doi = "10.1016/j.ccell.2021.02.017",

language = "English",

volume = "39",

pages = "451--453",

journal = "Cancer Cell",

issn = "1878-3686",

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number = "4",

}

TY - JOUR

T1 - Pancreatic cancer is suppressed by fibroblast-derived collagen I

AU - Madsen, Chris

PY - 2021/4/12

Y1 - 2021/4/12

N2 - Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immunesuppression and accelerates progression of disease.

AB - Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immunesuppression and accelerates progression of disease.

U2 - 10.1016/j.ccell.2021.02.017

DO - 10.1016/j.ccell.2021.02.017

M3 - Review article

C2 - 33711271

SN - 1878-3686

VL - 39

SP - 451

EP - 453

JO - Cancer Cell

JF - Cancer Cell

IS - 4

ER -

Pancreatic cancer is suppressed by fibroblast-derived collagen I

Abstract

Subject classification (UKÄ)

UN SDGs

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