Pancreatic lipase related protein 2, but not classical lipase hydrolyzes galactolipids

Lena Andersson; Frederic Carriere; Mark E Lowe; Åke Nilsson; Robert Verger

doi:10.1016/0005-2760(96)00068-9

Pancreatic lipase related protein 2, but not classical lipase hydrolyzes galactolipids

Lena Andersson, Frederic Carriere, Mark E Lowe, Åke Nilsson, Robert Verger

Research output: Contribution to journal › Article › peer-review

Abstract

The pancreatic lipase family contains three subfamilies, the 'classical' lipases and the pancreatic lipase-related proteins 1 (PLRP1) and 2 (PLRP2). Galactolipids are present in membranes of leaves and vegetables and consist of digalactosyldiacylglycerol (DGalDG) monogalactosyldiacylglycerol (MGalDG) and sulfoquinovosyldiacylglycerol (SQDG). These lipids were incubated with PLRP2 from guinea-pig (GPLRP2) and rat (RPLRP2). In the presence of bile salts DGalDG was efficiently hydrolyzed by GPLRP2 and, although less efficiently, by RPLRP2 to digalactosylmonoacylglycerol (DGalMG), free fatty acids and water-soluble galactose-containing compounds. Also, MGalDG and SQDG were hydrolyzed by GPLRP2 and RPLRP2. These data suggest a possible role of PLRP2 in the digestion of dietary galactolipids

Original language	English
Pages (from-to)	236-240
Journal	Biochimica et Biophysica Acta
Volume	1302
Issue number	3
DOIs	https://doi.org/10.1016/0005-2760(96)00068-9
Publication status	Published - 1996 Aug 1

Subject classification (UKÄ)

Gastroenterology and Hepatology

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10.1016/0005-2760(96)00068-9

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title = "Pancreatic lipase related protein 2, but not classical lipase hydrolyzes galactolipids",

abstract = "The pancreatic lipase family contains three subfamilies, the 'classical' lipases and the pancreatic lipase-related proteins 1 (PLRP1) and 2 (PLRP2). Galactolipids are present in membranes of leaves and vegetables and consist of digalactosyldiacylglycerol (DGalDG) monogalactosyldiacylglycerol (MGalDG) and sulfoquinovosyldiacylglycerol (SQDG). These lipids were incubated with PLRP2 from guinea-pig (GPLRP2) and rat (RPLRP2). In the presence of bile salts DGalDG was efficiently hydrolyzed by GPLRP2 and, although less efficiently, by RPLRP2 to digalactosylmonoacylglycerol (DGalMG), free fatty acids and water-soluble galactose-containing compounds. Also, MGalDG and SQDG were hydrolyzed by GPLRP2 and RPLRP2. These data suggest a possible role of PLRP2 in the digestion of dietary galactolipids",

author = "Lena Andersson and Frederic Carriere and Lowe, {Mark E} and {\AA}ke Nilsson and Robert Verger",

year = "1996",

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doi = "10.1016/0005-2760(96)00068-9",

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T1 - Pancreatic lipase related protein 2, but not classical lipase hydrolyzes galactolipids

AU - Andersson, Lena

AU - Carriere, Frederic

AU - Lowe, Mark E

AU - Nilsson, Åke

AU - Verger, Robert

PY - 1996/8/1

Y1 - 1996/8/1

N2 - The pancreatic lipase family contains three subfamilies, the 'classical' lipases and the pancreatic lipase-related proteins 1 (PLRP1) and 2 (PLRP2). Galactolipids are present in membranes of leaves and vegetables and consist of digalactosyldiacylglycerol (DGalDG) monogalactosyldiacylglycerol (MGalDG) and sulfoquinovosyldiacylglycerol (SQDG). These lipids were incubated with PLRP2 from guinea-pig (GPLRP2) and rat (RPLRP2). In the presence of bile salts DGalDG was efficiently hydrolyzed by GPLRP2 and, although less efficiently, by RPLRP2 to digalactosylmonoacylglycerol (DGalMG), free fatty acids and water-soluble galactose-containing compounds. Also, MGalDG and SQDG were hydrolyzed by GPLRP2 and RPLRP2. These data suggest a possible role of PLRP2 in the digestion of dietary galactolipids

AB - The pancreatic lipase family contains three subfamilies, the 'classical' lipases and the pancreatic lipase-related proteins 1 (PLRP1) and 2 (PLRP2). Galactolipids are present in membranes of leaves and vegetables and consist of digalactosyldiacylglycerol (DGalDG) monogalactosyldiacylglycerol (MGalDG) and sulfoquinovosyldiacylglycerol (SQDG). These lipids were incubated with PLRP2 from guinea-pig (GPLRP2) and rat (RPLRP2). In the presence of bile salts DGalDG was efficiently hydrolyzed by GPLRP2 and, although less efficiently, by RPLRP2 to digalactosylmonoacylglycerol (DGalMG), free fatty acids and water-soluble galactose-containing compounds. Also, MGalDG and SQDG were hydrolyzed by GPLRP2 and RPLRP2. These data suggest a possible role of PLRP2 in the digestion of dietary galactolipids

U2 - 10.1016/0005-2760(96)00068-9

DO - 10.1016/0005-2760(96)00068-9

M3 - Article

SN - 0006-3002

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JO - Biochimica et Biophysica Acta

JF - Biochimica et Biophysica Acta

IS - 3

ER -

Pancreatic lipase related protein 2, but not classical lipase hydrolyzes galactolipids

Abstract

Subject classification (UKÄ)

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