Panel 8: Report on Recent Advances in Molecular and Cellular Biochemistry

Diego Preciado, Anna Granath, Jizhen Lin, Stéphanie Val, Arwa Kurabi, Nikki Johnston, Shyan Vijayasekaran, Tulio Valdez, Didier Depireux, Ann Hermansson

Research output: Contribution to journalArticlepeer-review

3 Citations (SciVal)

Abstract

Objectives: To update the medical literature on recent cellular and molecular advances in otitis media disease models with a principal focus on developments in the past 5 years. We also aim to explain recent translational advances in cellular and molecular biology that have influenced our understanding and management of otitis media. Data Sources: PubMed-indexed peer-reviewed articles. Review Methods: A comprehensive review of the literature was conducted with the term otitis media and the following search terms: molecular biology, cell biology, innate immunity, oxidative stress, mucins, molecular diagnostics. Included articles were published in the English language from January 1, 2010, to July 31, 2015. Implications for Practice: The molecular understanding of otitis media disease progression has rapidly advanced over the last 5 years. The roles of inflammation, mucins, and cell signaling mechanisms have been elucidated and defined. Advances in the field provide a plethora of opportunities for innovative molecular targeting in the development of novel therapeutic strategies for otitis media.

Original languageEnglish
Pages (from-to)S106-S113
JournalOtolaryngology - Head and Neck Surgery
Volume156
Issue number4_suppl
DOIs
Publication statusPublished - 2017 Apr 1

Subject classification (UKÄ)

  • Cell and Molecular Biology
  • Otorhinolaryngology

Keywords

  • biofilms
  • cell biology
  • innate immunity
  • molecular biology
  • molecular diagnostics
  • mucins
  • NETs
  • optical coherence tomography
  • otitis media
  • oxidative stress
  • Toll-like receptors

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