Patch testing with Finn Chambers could give false positive reactions in patients with contact allergy to aluminium

Lisbeth Rosholm Comstedt, Jakob Dahlin, Magnus Bruze, Yolanda Hedberg, Mihály Matura, Cecilia Svedman

Research output: Contribution to journalArticlepeer-review

Abstract

Background
Earlier laboratory studies have shown that sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride trigger the release of aluminium (Al) from Finn Chambers (FC).

Objectives
To investigate whether aluminium realease from FC could influence the diagnostic outcome of patch testing with FC.

Method
A retrospective analysis of patch test results from 2010 to 2019 was performed. A two-sided Fisher's exact test was used to calculate any overrepresentation of contact allergy to Al among patients with positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride.

Results
A total of 5446 patients had been tested with FC during the study period. There was a significant overrepresentation of contact allergy to Al among patients with positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride. Patients with a strong Al allergy had significantly higher amounts of concomitant reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride compared to patients with weak Al allergy. These results were not seen for patients tested with Finn Chambers AQUA.

Conclusion
In patients with contact allergy to Al, patch testing with Finn chambers could give false-positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride.
Original languageEnglish
Number of pages8
JournalContact Dermatitis
DOIs
Publication statusPublished - 2021 Apr 26

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases

Keywords

  • aluminium corrosion
  • caine mix II
  • contact allergy to aluminium
  • Finn chambers
  • Myroxylon pereirae
  • palladium chloride
  • sodium tetrachloropalladate

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