Patch testing with methylchloroisothiazolinone/methylisothiazolinone 200 ppm aq. detects significantly more contact allergy than 100 ppm. A multicentre study within the European Environmental and Contact Dermatitis Research Group.

Magnus Bruze, Marléne Isaksson, Birgitta Gruvberger, Klaus E Andersen, Margarida Gonçalo, An Goossens, Jeanne D Johansen, Howard I Maibach, Thomas Rustemeyer, Christophe-J Le Coz, Ian R White

Research output: Contribution to journalArticlepeer-review

19 Citations (SciVal)

Abstract

Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are the active ingredients in commonly used preservative systems (e.g. Kathon CG(®) ). MCI/MI is present in the European baseline patch test series at 100 ppm aq. Since 1986, 200 ppm (dose 0.006 mg/cm(2) ) has been used in Sweden without causing skin irritation. Centres in Spain, the United Kingdom and Ireland have also used 200 ppm in their baseline series.
Original languageEnglish
Pages (from-to)31-34
JournalContact Dermatitis
Volume71
Issue number1
DOIs
Publication statusPublished - 2014

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Occupational and Environmental Dermatology Unit (013241310), Pediatrics/Urology/Gynecology/Endocrinology (013240400)

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases

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