PCNA, Ki-67, p53, bcl-2 and prognosis in intraoral squamous cell carcinoma of the head and neck

K. Nylander, E. B. Schildt, M. Eriksson, Göran Roos

Research output: Contribution to journalArticlepeer-review

Abstract

Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow-up of 4-14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki-67, p53, bcl-2 and presence of mutations in the p53 gene. The turnout site was not associated with the different parameters calculated. PCNA and Ki-67 labelling showed median values of 56% and 32%, respectively, and neither antigen was of predictive value. Fiftyfive percent of the tumours expressed p53, and 38 (48%) had mutations in the p53 gene. No association between the presence of p53 protein or mutations in the p53 gene and clinical outcome was found. Bcl-2 positivity was detected in a minor fraction (10%) of the tumours.

Original languageEnglish
Article number591251
Pages (from-to)101-110
JournalAnalytical Cellular Pathology
Volume14
DOIs
Publication statusPublished - 1997 Jan 1
Externally publishedYes

Free keywords

  • head and neck
  • Immunohistochemistry
  • Mutation analysis
  • Prognosis
  • Squamous call carcinoma

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