Abstract
Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow-up of 4-14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki-67, p53, bcl-2 and presence of mutations in the p53 gene. The turnout site was not associated with the different parameters calculated. PCNA and Ki-67 labelling showed median values of 56% and 32%, respectively, and neither antigen was of predictive value. Fiftyfive percent of the tumours expressed p53, and 38 (48%) had mutations in the p53 gene. No association between the presence of p53 protein or mutations in the p53 gene and clinical outcome was found. Bcl-2 positivity was detected in a minor fraction (10%) of the tumours.
Original language | English |
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Article number | 591251 |
Pages (from-to) | 101-110 |
Journal | Analytical Cellular Pathology |
Volume | 14 |
DOIs | |
Publication status | Published - 1997 Jan 1 |
Externally published | Yes |
Free keywords
- head and neck
- Immunohistochemistry
- Mutation analysis
- Prognosis
- Squamous call carcinoma