Abstract
Material and methods: In all, 237 consecutive patients with a perforated peptic ulcer admitted from 1974-1992 and 125 consecutive patients with an oesophageal perforation admitted from 1970-2006 to Lund University hospital were studied retrospectively. Prognostic factors were evaluated using the Cox proportional hazards model.
All cases of gastro-duodenal ulcer perforations diagnosed in Sweden from 1974 to 2002 were identified using the National Hospital Discharge Register and incidence figures were calculated. Information on sales of ASA/NSAID´s was obtained from the National Prescription Survey.
Results and conclusions: Incidence of peptic-ulcer perforations has decreased in Sweden since the late 1980?s, after the introduction of the proton pump inhibitors (PPI), despite an increase in sales of NSAID/ASA of 28% during this period. The reason for this is probably multifactorial (cohort phenomena, smoking habits, Helicobacter pylori), but the increasing use of PPI might have protected the population from NSAID complications and thus contributed to the fall in incidence.
In oesophageal perforations, a CAT scan or a contrast plain film investigation had the highest degree of true positive investigations. Regarding peptic ulcer perforations a plain film was the most widely used investigation and it was true positive in 75% of cases.
In oesophageal perforations, pre-operative ASA-score was the only factor that significantly influenced outcome. Perforations in the thoracic part of the oesophagus had worse prognosis than perforations in the neck. Treatment with a covered stent with or without open drainage had the lowest mortality. Diversion by a pharyngostoma did not improve survival.
In patients with a peptic ulcer perforation, age >75 years, significant co-morbidity, location in the stomach and > 24 hours from symptoms to operation, had a negative impact on outcome. Treatment with simple closure resulted in the lowest mortality.
All cases of gastro-duodenal ulcer perforations diagnosed in Sweden from 1974 to 2002 were identified using the National Hospital Discharge Register and incidence figures were calculated. Information on sales of ASA/NSAID´s was obtained from the National Prescription Survey.
Results and conclusions: Incidence of peptic-ulcer perforations has decreased in Sweden since the late 1980?s, after the introduction of the proton pump inhibitors (PPI), despite an increase in sales of NSAID/ASA of 28% during this period. The reason for this is probably multifactorial (cohort phenomena, smoking habits, Helicobacter pylori), but the increasing use of PPI might have protected the population from NSAID complications and thus contributed to the fall in incidence.
In oesophageal perforations, a CAT scan or a contrast plain film investigation had the highest degree of true positive investigations. Regarding peptic ulcer perforations a plain film was the most widely used investigation and it was true positive in 75% of cases.
In oesophageal perforations, pre-operative ASA-score was the only factor that significantly influenced outcome. Perforations in the thoracic part of the oesophagus had worse prognosis than perforations in the neck. Treatment with a covered stent with or without open drainage had the lowest mortality. Diversion by a pharyngostoma did not improve survival.
In patients with a peptic ulcer perforation, age >75 years, significant co-morbidity, location in the stomach and > 24 hours from symptoms to operation, had a negative impact on outcome. Treatment with simple closure resulted in the lowest mortality.
| Original language | English |
|---|---|
| Qualification | Doctor |
| Awarding Institution |
|
| Supervisors/Advisors |
|
| Award date | 2007 Jun 2 |
| Publisher | |
| ISBN (Print) | 978-91-85559-81-7 |
| Publication status | Published - 2007 |
Bibliographical note
Defence detailsDate: 2007-06-02
Time: 10:00
Place: Föreläsningssal 1, Centralblocket, Universitetssjukhuset i Lund
External reviewer(s)
Name: Ekbom, Anders
Title: Professor
Affiliation: Enheten för Klinisk Epidemiologi, Karolinska institutet, Stockholm samt Harvard School of Public Hea
---
<div class="article_info">M Hermansson, C Staël von Holstein and T Zilling. <span class="article_issue_date">1997</span>. <span class="article_title">Peptic ulcer perforation before and after the introduction of H2-receptor blockers and proton pump inhibitors.</span> <span class="journal_series_title">Scand J Gastroenterol</span>, <span class="journal_volume">vol 32</span> <span class="journal_pages">pp 523-9</span>.</div>
<div class="article_info">M Hermansson, C Staël von Holstein and T Zilling. <span class="article_issue_date">1999</span>. <span class="article_title">Surgical approach and prognostic factors after peptic ulcer perforation.</span> <span class="journal_series_title">Eur J Surg</span>, <span class="journal_volume">vol 165</span> <span class="journal_pages">pp 566-72</span>.</div>
<div class="article_info">M Hermansson, A Ekedahl, J Ranstam and T Zilling. <span class="article_issue_date">2007</span>. <span class="article_title">Decreasing incidence of peptic ulcer complications despite increasing sales of prescribed NSAID:s, a study of the Swedish population from 1974-2002.</span> (submitted)</div>
<div class="article_info">M Hermansson, T Gudbjartsson, E Gyllestedt, G Hambreus, P Jönsson, R Lillo-Gil, U Smedh, B Walther and T Zilling. <span class="article_issue_date">2007</span>. <span class="article_title">Oesophageal perforation – treatment strategies for 125 consecutive patients.</span> (manuscript)</div>
Subject classification (UKÄ)
- Surgery
Free keywords
- orthopaedics
- Prognostic factors
- Incidence
- Surgery
- Diagnostic methods
- Proton pump inhibitors
- NSAID
- Peptic ulcer perforation
- Esophageal perforation
- traumatology
- Kirurgi
- ortopedi
- traumatologi