Perioperative autotransfusion and functional coagulation analysis in total hip replacement.

G Ekbäck, Ulf Schött, K Axelsson, M Carlberg

Research output: Contribution to journalArticlepeer-review


Functional coagulation analyses like Sonoclot and thromboelastography have not been evaluated during perioperative autotransfusion. We have prospectively studied three different transfusion regimes in 45 patients undergoing total hip arthroplasty. Blood losses were replaced either with heterologous erythrocyte concentrate (group I), intra- and postoperative autotransfusion of blood salvaged with cellsaver technique (group II) or predonated autologous erythrocyte concentrates together with salvaged blood (group III). Routine and functional coagulation analyses with a Sonoclot were performed preoperatively, 6 hours postoperatively (6 h), day 1-5 and 10. An early postoperative hypo- and late postoperative hypercoagulative phase could be detected with Sonoclot signs of platelet function and fibrin deposition in all groups. Sonoclot coagulation analyses better correlated to both blood loss and dextran dosage than APTT and platelet count in the routine coagulation analyses. Functional coagulation analysis has a potential use in individualizing plasmasubstitution and thromboprophylaxis regimes during autotransfusion in THR.
Original languageEnglish
Pages (from-to)390-395
JournalActa Anaesthesiologica Scandinavica
Issue number3
Publication statusPublished - 1995

Subject classification (UKÄ)

  • Anesthesiology and Intensive Care


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