Persistence and evolution of allergen-specific IgE repertoires during subcutaneous specific immunotherapy.

Mattias Levin, Jasmine J King, Jacob Glanville, Katherine J L Jackson, Timothy J Looney, Ramona A Hoh, Adriano Mari, Morgan Andersson, Lennart Greiff, Andrew Z Fire, Scott D Boyd, Mats Ohlin

Research output: Contribution to journalArticlepeer-review

Abstract

Specific immunotherapy (SIT) is the only treatment with proved long-term curative potential in patients with allergic disease. Allergen-specific IgE is the causative agent of allergic disease, and antibodies contribute to SIT, but the effects of SIT on aeroallergen-specific B-cell repertoires are not well understood.
Original languageEnglish
Pages (from-to)1535-1544
JournalThe Journal of Allergy and Clinical Immunology
Volume137
Issue number5
Early online date2015 Nov 7
DOIs
Publication statusPublished - 2016

Subject classification (UKÄ)

  • Respiratory Medicine and Allergy

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