Persistence of vaccine-derived poliovirus following a mass vaccination campaign in Cuba: implications for stopping polio vaccination after global eradication

P Más Lago; V M Cáceres; M A Galindo; H E Gary; M Valcarcel; J Barrios; L Sarmiento; I Avalos; J A Bravo; R Palomera; M Bello; R W Sutter; M A Pallansch; C A de Quadros

doi:10.1093/ije/30.5.1029

Persistence of vaccine-derived poliovirus following a mass vaccination campaign in Cuba: implications for stopping polio vaccination after global eradication

P Más Lago, V M Cáceres, M A Galindo, H E Gary, M Valcarcel, J Barrios, L Sarmiento, I Avalos, J A Bravo, R Palomera, M Bello, R W Sutter, M A Pallansch, C A de Quadros

Pedro Kouri Tropical Medicine Institute (IPK)

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: With substantial progress made toward polio eradication, developing the appropriate strategy for discontinuing global oral poliovirus vaccine (OPV) after global eradication becomes increasingly important. At issue is the theoretical risk of independent circulation of potentially virulent OPV-derived strains. Because Cuba uses OPV only in mass campaigns, it represents an ideal site to assess vaccine-derived poliovirus persistence.

METHODS: Infants born after the 1997 biannual mass campaigns were evaluated for past (neutralizing antibody) or current (virus excretion) evidence of vaccine-derived poliovirus exposure. We obtained sera and/or stool specimens from 861 infants; a second serum from 218 infants.

RESULTS: All stool specimens were poliovirus negative. Of 762 infants, 113 (14.8%) had initially detectable poliovirus type 1 antibody, 193 (25.3%) type 2, and 94 (12.3%) type 3. A precipitous antibody decline occurred in initially positive sera.

CONCLUSIONS: Our results suggest that in a country with high population immunity, vaccine-derived virus is unlikely to establish ongoing circulation.

Original language	English
Pages (from-to)	1029-1034
Journal	International Journal of Epidemiology
Volume	30
Issue number	5
DOIs	https://doi.org/10.1093/ije/30.5.1029
Publication status	Published - 2001 Oct
Externally published	Yes

Subject classification (UKÄ)

Infectious Medicine
Health Sciences

Free keywords

Cuba/epidemiology
Global Health
Humans
Immunization Programs
Infant
Infant, Newborn
Poliomyelitis/epidemiology
Poliovirus Vaccine, Oral

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ije/30.5.1029

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Más Lago, P., Cáceres, V. M., Galindo, M. A., Gary, H. E., Valcarcel, M., Barrios, J., Sarmiento, L., Avalos, I., Bravo, J. A., Palomera, R., Bello, M., Sutter, R. W., Pallansch, M. A., & de Quadros, C. A. (2001). Persistence of vaccine-derived poliovirus following a mass vaccination campaign in Cuba: implications for stopping polio vaccination after global eradication. International Journal of Epidemiology, 30(5), 1029-1034. https://doi.org/10.1093/ije/30.5.1029

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title = "Persistence of vaccine-derived poliovirus following a mass vaccination campaign in Cuba: implications for stopping polio vaccination after global eradication",

abstract = "BACKGROUND: With substantial progress made toward polio eradication, developing the appropriate strategy for discontinuing global oral poliovirus vaccine (OPV) after global eradication becomes increasingly important. At issue is the theoretical risk of independent circulation of potentially virulent OPV-derived strains. Because Cuba uses OPV only in mass campaigns, it represents an ideal site to assess vaccine-derived poliovirus persistence.METHODS: Infants born after the 1997 biannual mass campaigns were evaluated for past (neutralizing antibody) or current (virus excretion) evidence of vaccine-derived poliovirus exposure. We obtained sera and/or stool specimens from 861 infants; a second serum from 218 infants.RESULTS: All stool specimens were poliovirus negative. Of 762 infants, 113 (14.8%) had initially detectable poliovirus type 1 antibody, 193 (25.3%) type 2, and 94 (12.3%) type 3. A precipitous antibody decline occurred in initially positive sera.CONCLUSIONS: Our results suggest that in a country with high population immunity, vaccine-derived virus is unlikely to establish ongoing circulation.",

keywords = "Cuba/epidemiology, Global Health, Humans, Immunization Programs, Infant, Infant, Newborn, Poliomyelitis/epidemiology, Poliovirus Vaccine, Oral",

author = "{M{\'a}s Lago}, P and C{\'a}ceres, {V M} and Galindo, {M A} and Gary, {H E} and M Valcarcel and J Barrios and L Sarmiento and I Avalos and Bravo, {J A} and R Palomera and M Bello and Sutter, {R W} and Pallansch, {M A} and {de Quadros}, {C A}",

year = "2001",

month = oct,

doi = "10.1093/ije/30.5.1029",

language = "English",

volume = "30",

pages = "1029--1034",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "5",

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Más Lago, P, Cáceres, VM, Galindo, MA, Gary, HE, Valcarcel, M, Barrios, J, Sarmiento, L, Avalos, I, Bravo, JA, Palomera, R, Bello, M, Sutter, RW, Pallansch, MA & de Quadros, CA 2001, 'Persistence of vaccine-derived poliovirus following a mass vaccination campaign in Cuba: implications for stopping polio vaccination after global eradication', International Journal of Epidemiology, vol. 30, no. 5, pp. 1029-1034. https://doi.org/10.1093/ije/30.5.1029

TY - JOUR

T1 - Persistence of vaccine-derived poliovirus following a mass vaccination campaign in Cuba

T2 - implications for stopping polio vaccination after global eradication

AU - Más Lago, P

AU - Cáceres, V M

AU - Galindo, M A

AU - Gary, H E

AU - Valcarcel, M

AU - Barrios, J

AU - Sarmiento, L

AU - Avalos, I

AU - Bravo, J A

AU - Palomera, R

AU - Bello, M

AU - Sutter, R W

AU - Pallansch, M A

AU - de Quadros, C A

PY - 2001/10

Y1 - 2001/10

N2 - BACKGROUND: With substantial progress made toward polio eradication, developing the appropriate strategy for discontinuing global oral poliovirus vaccine (OPV) after global eradication becomes increasingly important. At issue is the theoretical risk of independent circulation of potentially virulent OPV-derived strains. Because Cuba uses OPV only in mass campaigns, it represents an ideal site to assess vaccine-derived poliovirus persistence.METHODS: Infants born after the 1997 biannual mass campaigns were evaluated for past (neutralizing antibody) or current (virus excretion) evidence of vaccine-derived poliovirus exposure. We obtained sera and/or stool specimens from 861 infants; a second serum from 218 infants.RESULTS: All stool specimens were poliovirus negative. Of 762 infants, 113 (14.8%) had initially detectable poliovirus type 1 antibody, 193 (25.3%) type 2, and 94 (12.3%) type 3. A precipitous antibody decline occurred in initially positive sera.CONCLUSIONS: Our results suggest that in a country with high population immunity, vaccine-derived virus is unlikely to establish ongoing circulation.

AB - BACKGROUND: With substantial progress made toward polio eradication, developing the appropriate strategy for discontinuing global oral poliovirus vaccine (OPV) after global eradication becomes increasingly important. At issue is the theoretical risk of independent circulation of potentially virulent OPV-derived strains. Because Cuba uses OPV only in mass campaigns, it represents an ideal site to assess vaccine-derived poliovirus persistence.METHODS: Infants born after the 1997 biannual mass campaigns were evaluated for past (neutralizing antibody) or current (virus excretion) evidence of vaccine-derived poliovirus exposure. We obtained sera and/or stool specimens from 861 infants; a second serum from 218 infants.RESULTS: All stool specimens were poliovirus negative. Of 762 infants, 113 (14.8%) had initially detectable poliovirus type 1 antibody, 193 (25.3%) type 2, and 94 (12.3%) type 3. A precipitous antibody decline occurred in initially positive sera.CONCLUSIONS: Our results suggest that in a country with high population immunity, vaccine-derived virus is unlikely to establish ongoing circulation.

KW - Cuba/epidemiology

KW - Global Health

KW - Humans

KW - Immunization Programs

KW - Infant

KW - Infant, Newborn

KW - Poliomyelitis/epidemiology

KW - Poliovirus Vaccine, Oral

U2 - 10.1093/ije/30.5.1029

DO - 10.1093/ije/30.5.1029

M3 - Article

C2 - 11689516

SN - 0300-5771

VL - 30

SP - 1029

EP - 1034

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 5

ER -

Persistence of vaccine-derived poliovirus following a mass vaccination campaign in Cuba: implications for stopping polio vaccination after global eradication

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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