Persistent production of neurons from adult brain stem cells during recovery after stroke.

Per Thored, Andreas Arvidsson, Emanuele Cacci, Henrik Ahlenius, Therese Kallur, Vladimer Darsalia, Christine Ekdahl Clementson, Zaal Kokaia, Olle Lindvall

Research output: Contribution to journalArticlepeer-review

579 Citations (SciVal)

Abstract

Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons that may replace those that have died after stroke; however, the neurogenic response has been considered acute and transient, yielding only small numbers of neurons. In contrast, we show herein that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. The directed migration of the new neurons toward the ischemic damage is regulated by stromal cell-derived factor-la and its receptor CXCR4. These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke.
Original languageEnglish
Pages (from-to)739-747
JournalStem Cells
Volume24
Issue number3
DOIs
Publication statusPublished - 2006

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Restorative Neurology (0131000160), Stem Cell Center (013041110), Neurology, Lund (013027000)

Subject classification (UKÄ)

  • Cell and Molecular Biology

Keywords

  • striatum
  • neurogenesis
  • stroke
  • stem cells

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