Abstract
Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons that may replace those that have died after stroke; however, the neurogenic response has been considered acute and transient, yielding only small numbers of neurons. In contrast, we show herein that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. The directed migration of the new neurons toward the ischemic damage is regulated by stromal cell-derived factor-la and its receptor CXCR4. These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke.
| Original language | English |
|---|---|
| Pages (from-to) | 739-747 |
| Journal | Stem Cells |
| Volume | 24 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2006 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Restorative Neurology (0131000160), Stem Cell Center (013041110), Neurology, Lund (013027000)
Subject classification (UKÄ)
- Cell and Molecular Biology
Free keywords
- striatum
- neurogenesis
- stroke
- stem cells