TY - GEN
T1 - Personalised breast cancer screening with selective addition of digital breast tomosynthesis through artificial intelligence
AU - Dahlblom, Victor
AU - Tingberg, Anders
AU - Zackrisson, Sophia
AU - Dustler, Magnus
PY - 2020
Y1 - 2020
N2 - Breast cancer screening is predominantly performed using digital mammography (DM), but higher sensitivity has been demonstrated with digital breast tomosynthesis (DBT). A partial DBT screening in selected groups with a clear benefit from DBT might be more feasible than a full implementation, and using artificial intelligence (AI) to select women for DBT might be a possibility. This study used data from Malmö Breast Tomosynthesis Screening Trial, where all women prospectively were examined with separately read DM and DBT. We retrospectively analysed DM examinations (n=14768) with a breast cancer detection software and used the provided risk score (1-10) for risk stratification. We tested how different score thresholds for adding DBT to an initial DM affects the number of detected cancers, additional DBT examinations needed, detection rate, and false positives. If using a threshold of 9.0, 25 (26 %) more cancers would be detected compared to using DM alone. Of the 41 cancers only detected on DBT, 61 % would be detected, with only 1797 (12 %) of the women examined with both DM and DBT. The detection rate for the added DBT would be 14/1000 women, while the false positive recalls would be increased with 58 (21 %). Using DBT only for selected high gain cases could be an alternative to a complete DBT screening. AI could be used for analysing DM to identify high gain cases, where DBT can be added during the same visit. There might be logistical challenges and further studies in a prospective setting are necessary.
AB - Breast cancer screening is predominantly performed using digital mammography (DM), but higher sensitivity has been demonstrated with digital breast tomosynthesis (DBT). A partial DBT screening in selected groups with a clear benefit from DBT might be more feasible than a full implementation, and using artificial intelligence (AI) to select women for DBT might be a possibility. This study used data from Malmö Breast Tomosynthesis Screening Trial, where all women prospectively were examined with separately read DM and DBT. We retrospectively analysed DM examinations (n=14768) with a breast cancer detection software and used the provided risk score (1-10) for risk stratification. We tested how different score thresholds for adding DBT to an initial DM affects the number of detected cancers, additional DBT examinations needed, detection rate, and false positives. If using a threshold of 9.0, 25 (26 %) more cancers would be detected compared to using DM alone. Of the 41 cancers only detected on DBT, 61 % would be detected, with only 1797 (12 %) of the women examined with both DM and DBT. The detection rate for the added DBT would be 14/1000 women, while the false positive recalls would be increased with 58 (21 %). Using DBT only for selected high gain cases could be an alternative to a complete DBT screening. AI could be used for analysing DM to identify high gain cases, where DBT can be added during the same visit. There might be logistical challenges and further studies in a prospective setting are necessary.
KW - Artificial intelligence
KW - Breast cancer screening
KW - Digital breast tomosynthesis
KW - Personalised screening
UR - http://www.scopus.com/inward/record.url?scp=85086140189&partnerID=8YFLogxK
U2 - 10.1117/12.2564344
DO - 10.1117/12.2564344
M3 - Paper in conference proceeding
AN - SCOPUS:85086140189
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - 15th International Workshop on Breast Imaging, IWBI 2020
A2 - Bosmans, Hilde
A2 - Marshall, Nicholas
A2 - Van Ongeval, Chantal
PB - SPIE
T2 - 15th International Workshop on Breast Imaging, IWBI 2020
Y2 - 25 May 2020 through 27 May 2020
ER -