Pharmacokinetic study of a systemically administered novel liposomal Temoporfin formulation in an animal tumor model

Jenny Svensson, Ann Johansson, Niels Bendsöe, Susanna Grafe, Tilmann Trebst, Stefan Andersson-Engels, Katarina Svanberg

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingResearchpeer-review

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Abstract

Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (international generic name Temoporfin) is a potent photosensitizer used for photodynamic therapy (PDT). In this study the pharmacokinetics of a systemically administered novel lipid formulation of Temoporfin in a murine tumor model has been investigated. Fluorescence spectroscopy measurements were performed at several time intervals following drug administration, yielding information on the Temoporfin concentration within excised internal organs as a function of time after injection. Both point-monitoring and imaging setups were used. The acquired fluorescence data were correlated to the concentration of Temoporfin obtained with High Performance Liquid Chromatography (HPLC). There was a significant correlation between the fluorescence methods and HPLC for most organs investigated. The pharmacokinetics of this new liposomal formulation of Temoporfin exhibited a rather flat temporal profile in the time interval 2-8 hours in this study.
Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
PagesT4270-T4270
Volume6427
DOIs
Publication statusPublished - 2007
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI - San Jose, CA, United States
Duration: 2007 Jan 202007 Jan 21

Publication series

Name
Volume6427
ISSN (Print)1605-7422
ISSN (Electronic)1042-4687

Conference

ConferenceOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI
Country/TerritoryUnited States
CitySan Jose, CA
Period2007/01/202007/01/21

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases

Keywords

  • Flat temporal profile
  • Temoporfin
  • Liposomal formulation

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