Pharmacokinetics of the MRI contrast agent gadobutrol in common marmoset monkeys (Callithrix jacchus)

Gunther Helms, Christina Schlumbohm, Enrique Garea-Rodriguez, Peter Dechent, Eberhard Fuchs

Research output: Contribution to journalArticlepeer-review

Abstract

Background: This study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. Methods: Local concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a triple dose of gadobutrol (0.3 mmol/kg) into the saphenous vein. A first-order single-compartment model was fitted to the measured R1 values and verified by blood analysis. Results: Slow injection (1.5 minutes) resulted in an elimination half-time of 26±4 minutes. After bolus injection (15 seconds), elimination was much slower (62±8 minutes) with 45% larger distribution volumes. Importantly, more gadobutrol entered the cerebrospinal fluid. Conclusions: Slow injection and a latency of about 20 minutes are recommended to avoid extravasation. Application of a triple dose of gadobutrol compensates for the fast elimination in healthy marmosets.
Original languageEnglish
Pages (from-to)290-296
Number of pages7
JournalJournal of Medical Primatology
Volume45
Issue number6
Early online date2016 Jul 15
DOIs
Publication statusPublished - 2016

Subject classification (UKÄ)

  • Pharmacology and Toxicology
  • Other Physics Topics

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