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Abstract
Background: This study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. Methods: Local concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a triple dose of gadobutrol (0.3 mmol/kg) into the saphenous vein. A first-order single-compartment model was fitted to the measured R1 values and verified by blood analysis. Results: Slow injection (1.5 minutes) resulted in an elimination half-time of 26±4 minutes. After bolus injection (15 seconds), elimination was much slower (62±8 minutes) with 45% larger distribution volumes. Importantly, more gadobutrol entered the cerebrospinal fluid. Conclusions: Slow injection and a latency of about 20 minutes are recommended to avoid extravasation. Application of a triple dose of gadobutrol compensates for the fast elimination in healthy marmosets.
Original language | English |
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Pages (from-to) | 290-296 |
Number of pages | 7 |
Journal | Journal of Medical Primatology |
Volume | 45 |
Issue number | 6 |
Early online date | 2016 Jul 15 |
DOIs | |
Publication status | Published - 2016 |
Subject classification (UKÄ)
- Pharmacology and Toxicology
- Other Physics Topics
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Dive into the research topics of 'Pharmacokinetics of the MRI contrast agent gadobutrol in common marmoset monkeys (Callithrix jacchus)'. Together they form a unique fingerprint.Projects
- 1 Finished
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Structural brain MRI and SPECT of common marmosets using clinical scanners
Helms, G. (Researcher), Schlumbohm, C. (Researcher), Garea Rodriguez, E. (Researcher), Stassart, R. (Researcher), Engeland, U. (Research engineer) & Fuchs, E. (PI)
2012/01/01 → 2015/12/31
Project: Research
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