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Abstract
Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. Thus, the integration of multiple technologies could help on clarify several aspects of neurobiology.
The aim of this thesis was to study the function of certain proteins and protein-protein interactions in murine brains by using mass spectrometry-based proteomics. Since one of the main switching mechanisms in cells is the
phosphorylation of proteins, the phosphoproteome of murine brains was specifically studied.
The results presented in this thesis let to the identification of phosphoproteins implicated in molecular pathways that could be responsible for brain impairment during certain conditions like obesity (Paper I and III), anxiety and depression (Paper III) and Parkinson´s disease (Paper IV). The findings of this thesis remarkably contribute to the proteomic and neurobiology fields and set phosphoproteomics as a powerful tool for the study of neuroscience.
The aim of this thesis was to study the function of certain proteins and protein-protein interactions in murine brains by using mass spectrometry-based proteomics. Since one of the main switching mechanisms in cells is the
phosphorylation of proteins, the phosphoproteome of murine brains was specifically studied.
The results presented in this thesis let to the identification of phosphoproteins implicated in molecular pathways that could be responsible for brain impairment during certain conditions like obesity (Paper I and III), anxiety and depression (Paper III) and Parkinson´s disease (Paper IV). The findings of this thesis remarkably contribute to the proteomic and neurobiology fields and set phosphoproteomics as a powerful tool for the study of neuroscience.
| Original language | English |
|---|---|
| Qualification | Doctor |
| Supervisors/Advisors |
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| Place of Publication | Lund |
| Publisher | |
| ISBN (Print) | 978-91-7753-610-9 |
| ISBN (electronic) | 978-91-7753-611-6 |
| Publication status | Published - 2018 |
Bibliographical note
Defence detailsDate: 2018-04-27
Time: 09:00
Place: lecture hall Lundmarksalen, Sölvegatan 27, Lund University, Faculty of Engineering LTH, Lund
External reviewer(s)
Name: Greggio, Elisa
Title: Associate professor
Affiliation: University of Padua, Italy
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Subject classification (UKÄ)
- Medical and Health Sciences
Free keywords
- Phosphoproteomics
- mass spectrometry
- brain disorders
- neurobiology
- phosphorylation
Fingerprint
Dive into the research topics of 'Phosphoproteomics to tackle brain disorders: Insight into the murine brain phosphoproteome'. Together they form a unique fingerprint.Research output
- 2 Article
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Protein synthesis is suppressed in sporadic and familial Parkinson’s disease by LRRK2
Deshpande, P., Flinkman, D., Hong, Y., Goltseva, E., Siino, V., Sun, L., Peltonen, S., Elo, L. L., Kaasinen, V., James, P. & Coffey, E. T., 2020 Nov, In: FASEB Journal. 34, 11, p. 14217-14233 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Impact of diet-induced obesity on the mouse brain phosphoproteome
Siino, V., Amato, A., Di Salvo, F., Caldara, G. F., Filogamo, M., James, P. & Vasto, S., 2018 Aug 1, In: Journal of Nutritional Biochemistry. 58, p. 102-109 8 p.Research output: Contribution to journal › Article › peer-review