Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study

U. Ekelund; L. Palla; S. Brage; Paul Franks; T. Peters; B. Balkau; M. J. T. Diaz; J. M. Huerta; C. Agnoli; L. Arriola; E. Ardanaz; H. Boeing; F. Clavel-Chapelon; F. Crowe; G. Fagherazzi; Leif Groop; P. Hainaut; N. Fons Johnsen; R. Kaaks; K. T. Khaw; T. J. Key; B. de Lauzon-Guillain; A. May; E. Monninkhof; C. Navarro; Peter Nilsson; J. Nautrup Ostergaard; T. Norat; K. Overvad; D. Palli; S. Panico; M. L. Redondo; F. Ricceri; O. Rolandsson; D. Romaguera; I. Romieu; M. J. Sanchez Perez; N. Slimani; A. Spijkerman; B. Teucher; A. Tjonneland; N. Travier; R. Tumino; W. Vos; M. Vigl; S. Sharp; C. Langenberg; N. Forouhi; E. Riboli; E. Feskens; N. J. Wareham

doi:10.1007/s00125-012-2532-2

Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study

U. Ekelund, L. Palla, S. Brage, Paul Franks, T. Peters, B. Balkau, M. J. T. Diaz, J. M. Huerta, C. Agnoli, L. Arriola, E. Ardanaz, H. Boeing, F. Clavel-Chapelon, F. Crowe, G. Fagherazzi, Leif Groop, P. Hainaut, N. Fons Johnsen, R. Kaaks, K. T. KhawT. J. Key, B. de Lauzon-Guillain, A. May, E. Monninkhof, C. Navarro, Peter Nilsson, J. Nautrup Ostergaard, T. Norat, K. Overvad, D. Palli, S. Panico, M. L. Redondo, F. Ricceri, O. Rolandsson, D. Romaguera, I. Romieu, M. J. Sanchez Perez, N. Slimani, A. Spijkerman, B. Teucher, A. Tjonneland, N. Travier, R. Tumino, W. Vos, M. Vigl, S. Sharp, C. Langenberg, N. Forouhi, E. Riboli, E. Feskens, N. J. Wareham

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Abstract

We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. The InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed by a four-category index. Obesity was measured by BMI and waist circumference (WC). Associations between physical activity, obesity and case-ascertained incident type 2 diabetes were analysed by Cox regression after adjusting for educational level, smoking status, alcohol consumption and energy intake. In combined analyses, individuals were stratified according to physical activity level, BMI and WC. A one-category difference in physical activity (equivalent to approximately 460 and 365 kJ/day in men and women, respectively) was independently associated with a 13% (HR 0.87, 95% CI 0.80, 0.94) and 7% (HR 0.93, 95% CI 0.89, 0.98) relative reduction in the risk of type 2 diabetes in men and women, respectively. Lower levels of physical activity were associated with an increased risk of diabetes across all strata of BMI. Comparing inactive with active individuals, the HRs were 1.44 (95% CI 1.11, 1.87) and 1.38 (95% CI 1.17, 1.62) in abdominally lean and obese inactive men, respectively, and 1.57 (95% CI 1.19, 2.07) and 1.19 (95% CI 1.01, 1.39) in abdominally lean and obese inactive women, respectively. Physical activity is associated with a reduction in the risk of developing type 2 diabetes across BMI categories in men and women, as well as in abdominally lean and obese men and women.

Original language	English
Pages (from-to)	1944-1952
Journal	Diabetologia
Volume	55
Issue number	7
DOIs	https://doi.org/10.1007/s00125-012-2532-2
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Subject classification (UKÄ)

Endocrinology and Diabetes

Free keywords

Abdominal obesity
Case-cohort study
Incident diabetes
Obesity
Physical activity

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10.1007/s00125-012-2532-2

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Ekelund, U., Palla, L., Brage, S., Franks, P., Peters, T., Balkau, B., Diaz, M. J. T., Huerta, J. M., Agnoli, C., Arriola, L., Ardanaz, E., Boeing, H., Clavel-Chapelon, F., Crowe, F., Fagherazzi, G., Groop, L., Hainaut, P., Johnsen, N. F., Kaaks, R., ... Wareham, N. J. (2012). Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study. Diabetologia, 55(7), 1944-1952. https://doi.org/10.1007/s00125-012-2532-2

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title = "Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study",

abstract = "We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. The InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed by a four-category index. Obesity was measured by BMI and waist circumference (WC). Associations between physical activity, obesity and case-ascertained incident type 2 diabetes were analysed by Cox regression after adjusting for educational level, smoking status, alcohol consumption and energy intake. In combined analyses, individuals were stratified according to physical activity level, BMI and WC. A one-category difference in physical activity (equivalent to approximately 460 and 365 kJ/day in men and women, respectively) was independently associated with a 13\% (HR 0.87, 95\% CI 0.80, 0.94) and 7\% (HR 0.93, 95\% CI 0.89, 0.98) relative reduction in the risk of type 2 diabetes in men and women, respectively. Lower levels of physical activity were associated with an increased risk of diabetes across all strata of BMI. Comparing inactive with active individuals, the HRs were 1.44 (95\% CI 1.11, 1.87) and 1.38 (95\% CI 1.17, 1.62) in abdominally lean and obese inactive men, respectively, and 1.57 (95\% CI 1.19, 2.07) and 1.19 (95\% CI 1.01, 1.39) in abdominally lean and obese inactive women, respectively. Physical activity is associated with a reduction in the risk of developing type 2 diabetes across BMI categories in men and women, as well as in abdominally lean and obese men and women.",

keywords = "Abdominal obesity, Case-cohort study, Incident diabetes, Obesity, Physical activity",

author = "U. Ekelund and L. Palla and S. Brage and Paul Franks and T. Peters and B. Balkau and Diaz, \{M. J. T.\} and Huerta, \{J. M.\} and C. Agnoli and L. Arriola and E. Ardanaz and H. Boeing and F. Clavel-Chapelon and F. Crowe and G. Fagherazzi and Leif Groop and P. Hainaut and Johnsen, \{N. Fons\} and R. Kaaks and Khaw, \{K. T.\} and Key, \{T. J.\} and \{de Lauzon-Guillain\}, B. and A. May and E. Monninkhof and C. Navarro and Peter Nilsson and Ostergaard, \{J. Nautrup\} and T. Norat and K. Overvad and D. Palli and S. Panico and Redondo, \{M. L.\} and F. Ricceri and O. Rolandsson and D. Romaguera and I. Romieu and \{Sanchez Perez\}, \{M. J.\} and N. Slimani and A. Spijkerman and B. Teucher and A. Tjonneland and N. Travier and R. Tumino and W. Vos and M. Vigl and S. Sharp and C. Langenberg and N. Forouhi and E. Riboli and E. Feskens and Wareham, \{N. J.\}",

year = "2012",

doi = "10.1007/s00125-012-2532-2",

language = "English",

volume = "55",

pages = "1944--1952",

journal = "Diabetologia",

issn = "1432-0428",

publisher = "Springer",

number = "7",

}

Ekelund, U, Palla, L, Brage, S, Franks, P, Peters, T, Balkau, B, Diaz, MJT, Huerta, JM, Agnoli, C, Arriola, L, Ardanaz, E, Boeing, H, Clavel-Chapelon, F, Crowe, F, Fagherazzi, G, Groop, L, Hainaut, P, Johnsen, NF, Kaaks, R, Khaw, KT, Key, TJ, de Lauzon-Guillain, B, May, A, Monninkhof, E, Navarro, C, Nilsson, P, Ostergaard, JN, Norat, T, Overvad, K, Palli, D, Panico, S, Redondo, ML, Ricceri, F, Rolandsson, O, Romaguera, D, Romieu, I, Sanchez Perez, MJ, Slimani, N, Spijkerman, A, Teucher, B, Tjonneland, A, Travier, N, Tumino, R, Vos, W, Vigl, M, Sharp, S, Langenberg, C, Forouhi, N, Riboli, E, Feskens, E & Wareham, NJ 2012, 'Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study', Diabetologia, vol. 55, no. 7, pp. 1944-1952. https://doi.org/10.1007/s00125-012-2532-2

TY - JOUR

T1 - Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study

AU - Ekelund, U.

AU - Palla, L.

AU - Brage, S.

AU - Franks, Paul

AU - Peters, T.

AU - Balkau, B.

AU - Diaz, M. J. T.

AU - Huerta, J. M.

AU - Agnoli, C.

AU - Arriola, L.

AU - Ardanaz, E.

AU - Boeing, H.

AU - Clavel-Chapelon, F.

AU - Crowe, F.

AU - Fagherazzi, G.

AU - Groop, Leif

AU - Hainaut, P.

AU - Johnsen, N. Fons

AU - Kaaks, R.

AU - Khaw, K. T.

AU - Key, T. J.

AU - de Lauzon-Guillain, B.

AU - May, A.

AU - Monninkhof, E.

AU - Navarro, C.

AU - Nilsson, Peter

AU - Ostergaard, J. Nautrup

AU - Norat, T.

AU - Overvad, K.

AU - Palli, D.

AU - Panico, S.

AU - Redondo, M. L.

AU - Ricceri, F.

AU - Rolandsson, O.

AU - Romaguera, D.

AU - Romieu, I.

AU - Sanchez Perez, M. J.

AU - Slimani, N.

AU - Spijkerman, A.

AU - Teucher, B.

AU - Tjonneland, A.

AU - Travier, N.

AU - Tumino, R.

AU - Vos, W.

AU - Vigl, M.

AU - Sharp, S.

AU - Langenberg, C.

AU - Forouhi, N.

AU - Riboli, E.

AU - Feskens, E.

AU - Wareham, N. J.

PY - 2012

Y1 - 2012

N2 - We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. The InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed by a four-category index. Obesity was measured by BMI and waist circumference (WC). Associations between physical activity, obesity and case-ascertained incident type 2 diabetes were analysed by Cox regression after adjusting for educational level, smoking status, alcohol consumption and energy intake. In combined analyses, individuals were stratified according to physical activity level, BMI and WC. A one-category difference in physical activity (equivalent to approximately 460 and 365 kJ/day in men and women, respectively) was independently associated with a 13% (HR 0.87, 95% CI 0.80, 0.94) and 7% (HR 0.93, 95% CI 0.89, 0.98) relative reduction in the risk of type 2 diabetes in men and women, respectively. Lower levels of physical activity were associated with an increased risk of diabetes across all strata of BMI. Comparing inactive with active individuals, the HRs were 1.44 (95% CI 1.11, 1.87) and 1.38 (95% CI 1.17, 1.62) in abdominally lean and obese inactive men, respectively, and 1.57 (95% CI 1.19, 2.07) and 1.19 (95% CI 1.01, 1.39) in abdominally lean and obese inactive women, respectively. Physical activity is associated with a reduction in the risk of developing type 2 diabetes across BMI categories in men and women, as well as in abdominally lean and obese men and women.

AB - We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. The InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed by a four-category index. Obesity was measured by BMI and waist circumference (WC). Associations between physical activity, obesity and case-ascertained incident type 2 diabetes were analysed by Cox regression after adjusting for educational level, smoking status, alcohol consumption and energy intake. In combined analyses, individuals were stratified according to physical activity level, BMI and WC. A one-category difference in physical activity (equivalent to approximately 460 and 365 kJ/day in men and women, respectively) was independently associated with a 13% (HR 0.87, 95% CI 0.80, 0.94) and 7% (HR 0.93, 95% CI 0.89, 0.98) relative reduction in the risk of type 2 diabetes in men and women, respectively. Lower levels of physical activity were associated with an increased risk of diabetes across all strata of BMI. Comparing inactive with active individuals, the HRs were 1.44 (95% CI 1.11, 1.87) and 1.38 (95% CI 1.17, 1.62) in abdominally lean and obese inactive men, respectively, and 1.57 (95% CI 1.19, 2.07) and 1.19 (95% CI 1.01, 1.39) in abdominally lean and obese inactive women, respectively. Physical activity is associated with a reduction in the risk of developing type 2 diabetes across BMI categories in men and women, as well as in abdominally lean and obese men and women.

KW - Abdominal obesity

KW - Case-cohort study

KW - Incident diabetes

KW - Obesity

KW - Physical activity

UR - https://www.scopus.com/pages/publications/84866420586

U2 - 10.1007/s00125-012-2532-2

DO - 10.1007/s00125-012-2532-2

M3 - Article

C2 - 22526603

SN - 1432-0428

VL - 55

SP - 1944

EP - 1952

JO - Diabetologia

JF - Diabetologia

IS - 7

ER -

Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study

Abstract

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