Pituitary adenylate cyclase activating polypeptide and migraine.

Alessandro S Zagami, Lars Edvinsson, Peter J Goadsby

Research output: Contribution to journalArticlepeer-review

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Abstract

Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg (n = 11), and further reduced interictally (n = 9). The data suggest PACAP, or its receptors, are a promising target for migraine therapeutics.
Original languageEnglish
Pages (from-to)1036-1040
JournalAnnals of Clinical and Translational Neurology
Volume1
Issue number12
DOIs
Publication statusPublished - 2014

Subject classification (UKÄ)

  • Other Clinical Medicine

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