Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis

Faisel Khan; Isabel Gonçalves; Angela C. Shore; Andrea Natali; Carlo Palombo; Helen M. Colhoun; Gerd Östling; Francesco Casanova; Cecilia Kennbäck; Kunihiko Aizawa; Margaretha Persson; Kim M. Gooding; David Strain; Helen Looker; Fiona Dove; Jill Belch; Silvia Pinnola; Elena Venturi; Michaela Kozakova; Jan Nilsson

doi:10.1016/j.xcrm.2022.100676

Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis

Faisel Khan, Isabel Gonçalves, Angela C. Shore, Andrea Natali, Carlo Palombo, Helen M. Colhoun, Gerd Östling, Francesco Casanova, Cecilia Kennbäck, Kunihiko Aizawa, Margaretha Persson, Kim M. Gooding, David Strain, Helen Looker, Fiona Dove, Jill Belch, Silvia Pinnola, Elena Venturi, Michaela Kozakova, Jan Nilsson

Research output: Contribution to journal › Article › peer-review

Abstract

The factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood. Here, we used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with 3-year change in carotid disease severity in a cohort of high-risk subjects treated with preventive therapy (n = 865). The results show that changes in intima-media thickness (IMT) are most pronounced in the carotid bulb. Progression of bulb IMT demonstrates independent associations with baseline bulb IMT, the plaque gray scale median (GSM), and the plasma level of platelet-derived growth factor (PDGF) (standardized β-coefficients and 95% confidence interval [CI] −0.14 [−0.06 to −0.02] p = 0.001, 0.15 [0.02–0.07] p = 0.001, and 0.20 [0.03–0.07] p < 0.001, respectively). Plasma PDGF correlates with the plaque GSM (0.23 [0.15–0.29] p < 0.001). These observations provide insight into the atherosclerotic process in high-risk subjects by showing that progression primarily occurs in fibrotic plaques and is associated with increased levels of PDGF.

Original language	English
Article number	100676
Journal	Cell Reports Medicine
Volume	3
Issue number	7
DOIs	https://doi.org/10.1016/j.xcrm.2022.100676
Publication status	Published - 2022 Jul 19

Subject classification (UKÄ)

Cardiac and Cardiovascular Systems

Free keywords

atherosclerosis
biomarkers
carotid ultrasound
intima-media thickness
risk factors
type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.xcrm.2022.100676Licence: CC BY

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Khan, F., Gonçalves, I., Shore, A. C., Natali, A., Palombo, C., Colhoun, H. M., Östling, G., Casanova, F., Kennbäck, C., Aizawa, K., Persson, M., Gooding, K. M., Strain, D., Looker, H., Dove, F., Belch, J., Pinnola, S., Venturi, E., Kozakova, M., & Nilsson, J. (2022). Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis. Cell Reports Medicine, 3(7), Article 100676. https://doi.org/10.1016/j.xcrm.2022.100676

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title = "Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis",

abstract = "The factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood. Here, we used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with 3-year change in carotid disease severity in a cohort of high-risk subjects treated with preventive therapy (n = 865). The results show that changes in intima-media thickness (IMT) are most pronounced in the carotid bulb. Progression of bulb IMT demonstrates independent associations with baseline bulb IMT, the plaque gray scale median (GSM), and the plasma level of platelet-derived growth factor (PDGF) (standardized β-coefficients and 95% confidence interval [CI] −0.14 [−0.06 to −0.02] p = 0.001, 0.15 [0.02–0.07] p = 0.001, and 0.20 [0.03–0.07] p < 0.001, respectively). Plasma PDGF correlates with the plaque GSM (0.23 [0.15–0.29] p < 0.001). These observations provide insight into the atherosclerotic process in high-risk subjects by showing that progression primarily occurs in fibrotic plaques and is associated with increased levels of PDGF.",

keywords = "atherosclerosis, biomarkers, carotid ultrasound, intima-media thickness, risk factors, type 2 diabetes",

author = "Faisel Khan and Isabel Gon{\c c}alves and Shore, {Angela C.} and Andrea Natali and Carlo Palombo and Colhoun, {Helen M.} and Gerd {\"O}stling and Francesco Casanova and Cecilia Kennb{\"a}ck and Kunihiko Aizawa and Margaretha Persson and Gooding, {Kim M.} and David Strain and Helen Looker and Fiona Dove and Jill Belch and Silvia Pinnola and Elena Venturi and Michaela Kozakova and Jan Nilsson",

year = "2022",

month = jul,

day = "19",

doi = "10.1016/j.xcrm.2022.100676",

language = "English",

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Khan, F, Gonçalves, I, Shore, AC, Natali, A, Palombo, C, Colhoun, HM, Östling, G, Casanova, F, Kennbäck, C, Aizawa, K, Persson, M, Gooding, KM, Strain, D, Looker, H, Dove, F, Belch, J, Pinnola, S, Venturi, E, Kozakova, M & Nilsson, J 2022, 'Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis', Cell Reports Medicine, vol. 3, no. 7, 100676. https://doi.org/10.1016/j.xcrm.2022.100676

TY - JOUR

T1 - Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis

AU - Khan, Faisel

AU - Gonçalves, Isabel

AU - Shore, Angela C.

AU - Natali, Andrea

AU - Palombo, Carlo

AU - Colhoun, Helen M.

AU - Östling, Gerd

AU - Casanova, Francesco

AU - Kennbäck, Cecilia

AU - Aizawa, Kunihiko

AU - Persson, Margaretha

AU - Gooding, Kim M.

AU - Strain, David

AU - Looker, Helen

AU - Dove, Fiona

AU - Belch, Jill

AU - Pinnola, Silvia

AU - Venturi, Elena

AU - Kozakova, Michaela

AU - Nilsson, Jan

PY - 2022/7/19

Y1 - 2022/7/19

N2 - The factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood. Here, we used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with 3-year change in carotid disease severity in a cohort of high-risk subjects treated with preventive therapy (n = 865). The results show that changes in intima-media thickness (IMT) are most pronounced in the carotid bulb. Progression of bulb IMT demonstrates independent associations with baseline bulb IMT, the plaque gray scale median (GSM), and the plasma level of platelet-derived growth factor (PDGF) (standardized β-coefficients and 95% confidence interval [CI] −0.14 [−0.06 to −0.02] p = 0.001, 0.15 [0.02–0.07] p = 0.001, and 0.20 [0.03–0.07] p < 0.001, respectively). Plasma PDGF correlates with the plaque GSM (0.23 [0.15–0.29] p < 0.001). These observations provide insight into the atherosclerotic process in high-risk subjects by showing that progression primarily occurs in fibrotic plaques and is associated with increased levels of PDGF.

AB - The factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood. Here, we used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with 3-year change in carotid disease severity in a cohort of high-risk subjects treated with preventive therapy (n = 865). The results show that changes in intima-media thickness (IMT) are most pronounced in the carotid bulb. Progression of bulb IMT demonstrates independent associations with baseline bulb IMT, the plaque gray scale median (GSM), and the plasma level of platelet-derived growth factor (PDGF) (standardized β-coefficients and 95% confidence interval [CI] −0.14 [−0.06 to −0.02] p = 0.001, 0.15 [0.02–0.07] p = 0.001, and 0.20 [0.03–0.07] p < 0.001, respectively). Plasma PDGF correlates with the plaque GSM (0.23 [0.15–0.29] p < 0.001). These observations provide insight into the atherosclerotic process in high-risk subjects by showing that progression primarily occurs in fibrotic plaques and is associated with increased levels of PDGF.

KW - atherosclerosis

KW - biomarkers

KW - carotid ultrasound

KW - intima-media thickness

KW - risk factors

KW - type 2 diabetes

U2 - 10.1016/j.xcrm.2022.100676

DO - 10.1016/j.xcrm.2022.100676

M3 - Article

C2 - 35858591

AN - SCOPUS:85134730726

SN - 2666-3791

VL - 3

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 7

M1 - 100676

ER -

Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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