Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.

Olga V Fedorova; Edward G Lakatta; Alexei Y Bagrov; Olle Melander

doi:10.1097/HJH.0000000000000437

Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.

Olga V Fedorova, Edward G Lakatta, Alexei Y Bagrov, Olle Melander

Research output: Contribution to journal › Article › peer-review

Abstract

Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity.

Original language	English
Pages (from-to)	534-541
Journal	Journal of Hypertension
Volume	33
Issue number	3
DOIs	https://doi.org/10.1097/HJH.0000000000000437
Publication status	Published - 2015

Subject classification (UKÄ)

Cardiology and Cardiovascular Disease

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10.1097/HJH.0000000000000437

http://www.ncbi.nlm.nih.gov/pubmed/25479026?dopt=Abstract

Cite this

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title = "Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.",

abstract = "Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity.",

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AU - Fedorova, Olga V

AU - Lakatta, Edward G

AU - Bagrov, Alexei Y

AU - Melander, Olle

PY - 2015

Y1 - 2015

N2 - Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity.

AB - Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity.

U2 - 10.1097/HJH.0000000000000437

DO - 10.1097/HJH.0000000000000437

M3 - Article

C2 - 25479026

SN - 1473-5598

VL - 33

SP - 534

EP - 541

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 3

ER -

Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.

Abstract

Subject classification (UKÄ)

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