Plasticity of Cerebrovascular Smooth Muscle Cells After Subarachnoid Hemorrhage

Lars Edvinsson, Stine Schmidt Larsen, Aida Maddahi, Janne Nielsen

Research output: Contribution to journalArticlepeer-review

14 Citations (SciVal)


Subarachnoid hemorrhage (SAH) is most often followed by a delayed phase of cerebral ischemia which is associated with high morbidity and mortality rates. The causes underlying this delayed phase are still unsettled, but are believed to include cerebral vasospasm, cortical spreading depression, inflammatory reactions, and microthrombosis. Additionally, a large body of evidence indicates that vascular plasticity plays an important role in SAH pathophysiology, and this review aims to summarize our current knowledge on the phenotypic changes of vascular smooth muscle cells of the cerebral vasculature following SAH. In light of the emerging view that the whole cerebral vasculature and the cells of the brain parenchyma should be viewed as one integrated neurovascular network, phenotypical changes are discussed both for the cerebral arteries and the microvasculature. Furthermore, the intracellular signaling involved in the vascular plasticity is discussed with a focus on the Raf-MEK1/2-ERK1/2 pathway which seems to play a crucial role in SAH pathology.
Original languageEnglish
Pages (from-to)365-376
JournalTranslational Stroke Research
Issue number3
Publication statusPublished - 2014

Subject classification (UKÄ)

  • Neurology


  • Subarachnoid hemorrhage
  • Vascular plasticity
  • Cerebral ischemia
  • Cerebral arteries
  • Microvasculature
  • Vasoconstrictor receptors
  • Pro-inflammatory cytokines


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