Platelet-derived S100A8/A9 and cardiovascular disease in systemic lupus erythematosus.

Christian Lood, Helena Tydén, Birgitta Gullstrand, Andreas Jönsen, Eva Källberg, Matthias Mörgelin, Robin Kahn, Iva Gunnarsson, Tomas Leanderson, Fredrik Ivars, Elisabet Svenungsson, Anders Bengtsson

Research output: Contribution to journalArticlepeer-review


S100A8/A9, a pro-inflammatory and pro-thrombotic protein complex, is increased in several diseases and high levels predispose to cardiovascular disease (CVD). Recently, platelet S100A8/A9 synthesis was described in mouse and humans in relation to CVD. However, the role of platelet S100A8/A9 in systemic lupus erythematosus (SLE), a disease with markedly increased cardiovascular morbidity, as well as the exact platelet distribution of the S100A8/A9 proteins has not been investigated.
Original languageEnglish
JournalArthritis & Rheumatology
Early online date2016 Mar 4
Publication statusPublished - 2016

Subject classification (UKÄ)

  • Cell and Molecular Biology


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