Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage.

Rundk Hwaiz; Milladur Rahman; Enming Zhang; Henrik Thorlacius

doi:10.1111/bph.13325

Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage.

Rundk Hwaiz, Milladur Rahman, Enming Zhang, Henrik Thorlacius

Research output: Contribution to journal › Article › peer-review

Abstract

Platelets are potent regulators of neutrophil accumulation in septic lung damage. We hypothesized that platelet-derived CXCL4 might support pulmonary neutrophilia in a murine model of abdominal sepsis.

Original language	English
Pages (from-to)	5347-5359
Journal	British Journal of Pharmacology
Volume	172
Issue number	22
DOIs	https://doi.org/10.1111/bph.13325
Publication status	Published - 2015

Subject classification (UKÄ)

Immunology in the Medical Area (including Cell and Immunotherapy)
Anesthesiology and Intensive Care

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10.1111/bph.13325

http://www.ncbi.nlm.nih.gov/pubmed/26478565?dopt=Abstract

Cite this

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title = "Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage.",

abstract = "Platelets are potent regulators of neutrophil accumulation in septic lung damage. We hypothesized that platelet-derived CXCL4 might support pulmonary neutrophilia in a murine model of abdominal sepsis.",

author = "Rundk Hwaiz and Milladur Rahman and Enming Zhang and Henrik Thorlacius",

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AU - Hwaiz, Rundk

AU - Rahman, Milladur

AU - Zhang, Enming

AU - Thorlacius, Henrik

PY - 2015

Y1 - 2015

N2 - Platelets are potent regulators of neutrophil accumulation in septic lung damage. We hypothesized that platelet-derived CXCL4 might support pulmonary neutrophilia in a murine model of abdominal sepsis.

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DO - 10.1111/bph.13325

M3 - Article

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SN - 1476-5381

VL - 172

SP - 5347

EP - 5359

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 22

ER -

Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage.

Abstract

Subject classification (UKÄ)

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