Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly.

Maria Herlin; Fiona McGuigan; Holger Luthman; Kristina Åkesson

doi:10.1016/j.bone.2015.05.035

Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly.

Maria Herlin, Fiona McGuigan, Holger Luthman, Kristina Åkesson

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Abstract

ALOX12 and ALOX15 encode arachidonate lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by ALOX12 and ALOX15 can activate the expression of the potent pro-inflammatory cytokine IL-6, and produce endogenous ligands for PPARG. In this study, polymorphisms in ALOX12, ALOX15, IL6 and PPARG were investigated for association with bone properties in young and elderly Swedish women.

Original language	English
Pages (from-to)	105-109
Journal	Bone
Volume	79
DOIs	https://doi.org/10.1016/j.bone.2015.05.035
Publication status	Published - 2015

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10.1016/j.bone.2015.05.035

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http://www.ncbi.nlm.nih.gov/pubmed/26036173?dopt=Abstract

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title = "Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly.",

abstract = "ALOX12 and ALOX15 encode arachidonate lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by ALOX12 and ALOX15 can activate the expression of the potent pro-inflammatory cytokine IL-6, and produce endogenous ligands for PPARG. In this study, polymorphisms in ALOX12, ALOX15, IL6 and PPARG were investigated for association with bone properties in young and elderly Swedish women.",

author = "Maria Herlin and Fiona McGuigan and Holger Luthman and Kristina {\AA}kesson",

year = "2015",

doi = "10.1016/j.bone.2015.05.035",

language = "English",

volume = "79",

pages = "105--109",

journal = "Bone",

issn = "1873-2763",

publisher = "Elsevier",

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T1 - Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly.

AU - Herlin, Maria

AU - McGuigan, Fiona

AU - Luthman, Holger

AU - Åkesson, Kristina

PY - 2015

Y1 - 2015

N2 - ALOX12 and ALOX15 encode arachidonate lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by ALOX12 and ALOX15 can activate the expression of the potent pro-inflammatory cytokine IL-6, and produce endogenous ligands for PPARG. In this study, polymorphisms in ALOX12, ALOX15, IL6 and PPARG were investigated for association with bone properties in young and elderly Swedish women.

AB - ALOX12 and ALOX15 encode arachidonate lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by ALOX12 and ALOX15 can activate the expression of the potent pro-inflammatory cytokine IL-6, and produce endogenous ligands for PPARG. In this study, polymorphisms in ALOX12, ALOX15, IL6 and PPARG were investigated for association with bone properties in young and elderly Swedish women.

U2 - 10.1016/j.bone.2015.05.035

DO - 10.1016/j.bone.2015.05.035

M3 - Article

C2 - 26036173

SN - 1873-2763

VL - 79

SP - 105

EP - 109

JO - Bone

JF - Bone

ER -

Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly.

Abstract

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