TY - JOUR
T1 - Prediagnostic intake of dairy products and dietary calcium and colorectal cancer survival - results from the EPIC cohort study.
AU - Dik, Vincent K
AU - Murphy, Neil
AU - Siersema, Peter D
AU - Fedirko, Veronika
AU - Jenab, Mazda
AU - Kong, So Y
AU - Hansen, Camilla P
AU - Overvad, Kim
AU - Tjonneland, Anne
AU - Olsen, Anja
AU - Dossus, Laure
AU - Racine, Antoine
AU - Bastide, Nadia
AU - Li, Kuanrong
AU - Kühn, Tilman
AU - Boeing, Heiner
AU - Aleksandrova, Krasimira
AU - Trichopoulou, Antonia
AU - Trichopoulos, Dimitrios
AU - Barbitsioti, Antonia
AU - Palli, Domenico
AU - Contiero, Paolo
AU - Vineis, Paolo
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Peeters, Petra H M
AU - Weiderpass, Elisabete
AU - Skeie, Guri
AU - Hjartaker, Anette
AU - Amiano, Pilar
AU - Sanchez, Maria-Jose
AU - Fonseca-Nunes, Ana
AU - Barricarte, Aurelio
AU - Chirlaque, Maria-Dolores
AU - Redondo, Maria-Luisa
AU - Jirström, Karin
AU - Manjer, Jonas
AU - Nilsson, Lena M
AU - Wennberg, Maria
AU - Bradbury, Kathryn E
AU - Khaw, Kay-Tee
AU - Wareham, Nicholas
AU - Cross, Amanda J
AU - Riboli, Elio
AU - Bueno-de-Mesquita, H Bas
N1 - The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Surgery Research Unit (013242220), Pathology, (Lund) (013030000)
PY - 2014
Y1 - 2014
N2 - Background We investigated whether prediagnostic reported intake of dairy products and dietary calcium are associated with colorectal cancer (CRC) survival. Methods Data from 3,859 subjects with CRC (42.1% male, mean age at diagnosis 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition (EPIC) cohort were analyzed. Intake of dairy products and dietary calcium was assessed at baseline (1992-2000) using validated, country-specific dietary questionnaires. Multivariable Cox regression models were used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (95%-CI) for CRC specific death (n=1,028) and all-cause death (n=1,525) for different quartiles of intake. Results The consumption of total dairy products was not statistically significantly associated with risk of CRC-specific death (adjusted HR Q4 vs. Q1: 1.17 95%-CI 0.97-1.43) nor of all-cause death (Q4 vs. Q1: 1.16 95%-CI 0.98-1.36). Multivariable adjusted HRs for CRC-specific death (Q4 vs. Q1) were 1.21 (95%-CI 0.99-1.48) for milk, 1.09 (95%-CI 0.88-1.34) for yoghurt and 0.93 (95%-CI 0.76-1.14) for cheese. The intake of dietary calcium was not associated with the risk of CRC-specific (adjusted HR Q4 vs. Q1: 1.01 95%-CI 0.81-1.26) nor of all-cause death (Q4 vs. Q1: 1.01 95%-CI 0.84-1.21). Conclusions The prediagnostic reported intake of dairy products and dietary calcium are not associated with disease-specific or all-cause risk of death in patients diagnosed with CRC. Impact The impact of diet on cancer survival is largely unknown. This study shows that despite it's inverse association with CRC risk, the prediagnostic intake of dairy and dietary calcium do not affect CRC survival.
AB - Background We investigated whether prediagnostic reported intake of dairy products and dietary calcium are associated with colorectal cancer (CRC) survival. Methods Data from 3,859 subjects with CRC (42.1% male, mean age at diagnosis 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition (EPIC) cohort were analyzed. Intake of dairy products and dietary calcium was assessed at baseline (1992-2000) using validated, country-specific dietary questionnaires. Multivariable Cox regression models were used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (95%-CI) for CRC specific death (n=1,028) and all-cause death (n=1,525) for different quartiles of intake. Results The consumption of total dairy products was not statistically significantly associated with risk of CRC-specific death (adjusted HR Q4 vs. Q1: 1.17 95%-CI 0.97-1.43) nor of all-cause death (Q4 vs. Q1: 1.16 95%-CI 0.98-1.36). Multivariable adjusted HRs for CRC-specific death (Q4 vs. Q1) were 1.21 (95%-CI 0.99-1.48) for milk, 1.09 (95%-CI 0.88-1.34) for yoghurt and 0.93 (95%-CI 0.76-1.14) for cheese. The intake of dietary calcium was not associated with the risk of CRC-specific (adjusted HR Q4 vs. Q1: 1.01 95%-CI 0.81-1.26) nor of all-cause death (Q4 vs. Q1: 1.01 95%-CI 0.84-1.21). Conclusions The prediagnostic reported intake of dairy products and dietary calcium are not associated with disease-specific or all-cause risk of death in patients diagnosed with CRC. Impact The impact of diet on cancer survival is largely unknown. This study shows that despite it's inverse association with CRC risk, the prediagnostic intake of dairy and dietary calcium do not affect CRC survival.
U2 - 10.1158/1055-9965.EPI-14-0172
DO - 10.1158/1055-9965.EPI-14-0172
M3 - Article
C2 - 24917183
SN - 1538-7755
VL - 23
SP - 1813
EP - 1823
JO - Cancer Epidemiology Biomarkers & Prevention
JF - Cancer Epidemiology Biomarkers & Prevention
IS - 9
ER -
